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Will King 1672210931 adding notes 12 months ago
Will King 4bf321b475 Notes and plans for writing 1 year ago
Will King 88be4b7a38 updated todo and plan 1 year ago

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Key points
This is an attempt at measuring the effect of extending the enrollment period.
The main issue is that the interaction between enrollment levels, enrollment status, and timing is confounded due to endogeneity.
This can be addressed
The other concerns are:
- endogeneity between market and population.
I this isn't a caual issue because it is contained between the two, can be treated as a single RV and controlled for together.
- ommitted variable bias. Did I forget or miss anything?
- The DAG is based on the details outlined based on FDA rules. I NEED TO LOOK THOSE UP AGAIN. The Assumptions that allow this to work are:
1. timeliness/accuracy in reporting open and close
2. updating certain details (open/close recruitment) is helpful because this is part of your marketing. (Concerns about measurement error)
3.
- Where did the DAG come from?
In spite of the endogeneity issue, I chose to continue modelling as if it were causal, because:
1. If we assume an intervetion that is handles the joint timing/enrollment status together, then it is causally identified (but hard to interpret)
- Walking away from identification is an issue in that you lose the use of this analysis
- Interpretation is as follows: changing enrollment status but breaking out of the standard timing of these things. Need a better way to say that.
2.
This is the only attempt I've found that tries to address this in a causal way, everything else is just descriptive.
It also differs in being the first econ literature on measuring the impact of an operational concern.

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Plan
get list of things that Tom says I'm Missing
- Needs more citations
- Standard econometric concerns: Endogenetiy, Simultineatiy, etc.
- Needs to justify why I am doing what I am doing. What do I add?
Marketwide attempt to measure the impact of enrollment, an operational concern.
-
Integrate additional literature I've worked with.
- How big of a concern is operational results (about 22% of failures)
- Topics of how to address issues and what issues arise are common (give a couple of examples)
- Efforts to reduce failures include better pharmokinetics, attempts at improving enrollment, better enrollment prediction (huge lit).
Then look at my outline:
- How can I adjust it to address those missing bits?
- How can I simplify the structure?
Maybe a discussion of concerns about simultineity/endogeneity/other confounds/etc is where I
bring up the confounding parameters and then build a list of how things interact.
I then use this to flesh out the DAG, and introduce the backdoor criterion.
I think I'll put this together as a bullet point draft, using the * and -
notation for paragraphs and sentences respectively. Try to get the main points
of each sentence/paragraph out.

@ -5,3 +5,64 @@
Need to decide whether or not to include this set of sentences.
**** [2025-01-18 Sat 11:58] [[[[file:/home/will/research/phd_deliverables/JobMarketPaper/Paper/sections/11_intro_and_lit.tex::45]]]]
decide whether to include these details here
** 2025-W17
*** 2025-04-21 Monday
**** [2025-04-21 Mon 11:17] Plan based on last weeks thinking things through
get list of things that Tom says I'm Missing
- Needs more citations
- Standard econometric concerns: Endogenetiy, Simultineatiy, etc.
- Needs to justify why I am doing what I am doing. What do I add?
Marketwide attempt to measure the impact of enrollment, an operational concern.
-
Integrate additional literature I've worked with.
- How big of a concern is operational results (about 22% of failures)
- Topics of how to address issues and what issues arise are common (give a couple of examples)
- Efforts to reduce failures include better pharmokinetics, attempts at improving enrollment, better enrollment prediction (huge lit).
Then look at my outline:
- How can I adjust it to address those missing bits?
- How can I simplify the structure?
Maybe a discussion of concerns about simultineity/endogeneity/other confounds/etc is where I
bring up the confounding parameters and then build a list of how things interact.
I then use this to flesh out the DAG, and introduce the backdoor criterion.
I think I'll put this together as a bullet point draft, using the * and -
notation for paragraphs and sentences respectively. Try to get the main points
of each sentence/paragraph out.
***** List of issues identified by Tom:
Reference style (Author year)
Reference better and more often.
Introduction needs to motivate the problem & what I am trying to do. (could use the sources I have on reasons for failures)
Various issues with tense etc. Use Claude.ai as editor for those.
Reorder sections or outline better
Causal inference vs DAG approach
- standard concens in causal inference
- DAG isn't causal inference in Toms view. He is right, DAG isn't but backdoor criterion is.
- Will need to discuss standard concerns and how they may be related and then incorporate that into the DAG
- Then will need to discuss backdoor criterion, the backdoor paths that exist, and choosing adjustment sets
- Replace bullet points with paragraphs (page 12) maybe use claude to convert that?
- Page 18 comment: Refer to Robins What IF book to get citation
Thoughts:
Chapter 10: Lists 3 sources of bias in preceeding chapters (7,8,9)
- Selection
- Measurement
- Confounders
As I understand it, setting up the graph allows you to note where you
might have issues with all 3. Do-calc gives you the adjustment set to
handle confounding and selection, while measurement is handled either
through modelling uncertanty or improving you measurement approach.
***** Reading to complete before rewriting:
I think I should start by rereading (and taking notes on) What If and
the Causal Mixtape.

@ -31,10 +31,10 @@
Realized that this was readded by mistake. I integrated lit review into intro in 11
** 2025-W04
*** 2025-01-20 Monday
**** TODO get a citation for the AACT project
**** DONE get a citation for the AACT project
[[[[file:/home/will/research/phd_deliverables/JobMarketPaper/Paper/sections/10_CausalStory.tex::114]]]]
*** 2025-01-23 Thursday
**** TODO Pickup citation fixes here
**** DONE Pickup citation fixes here
[[[[file:/home/will/research/phd_deliverables/JobMarketPaper/Paper/sections/06_Results.tex::174]]]]
** 2025-W05
*** 2025-01-30 Thursday
@ -42,3 +42,26 @@
So I need to create a cbo branch, remove references to betas, and finish
edits for submission tomorrow.
*** 2025-02-01 Saturday
**** TODO Plan for finishing jmp draft
***** analysis updates
****** DONE apply fixes to main analysis
****** DONE Remove rebased etc work
CLOSED: [2025-02-01 Sat 11:24]
****** DONE reenable fit summary
****** DONE increase sampleing size
****** DONE reparameterize sigma
CLOSED: [2025-02-01 Sat 13:27]
Chagned to lognormal
****** RECINDED remove last few groups that are not actual diseases
CLOSED: [2025-02-01 Sat 13:42]
decided to leave as is for now.
***** graphics updates
****** TODO remove quantity beta comparisons
****** TODO save status_diff analysis
****** TODO change distdiff by group to include more groups
***** writing updates
****** TODO Remove discussions related to previous betas work
****** TODO add in status_diff analysis
****** TODO change mode info to match new lognormal(location,scale) priors

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