added tables and references to intro

claude_rewrite
Will King 2 years ago
parent e5e052db35
commit 2fc6f08086

@ -16,31 +16,51 @@ are common
One essential step to introduce a novel pharmaceutical - or even One essential step to introduce a novel pharmaceutical - or even
to begin selling a generic compound - is to establish that the drug as packaged and sold will to begin selling a generic compound - is to establish that the drug as packaged and sold will
have acceptable safety and efficacy profiles. have acceptable safety and efficacy profiles.
When evaluating these compounds in a clinical trial, both outcomes are possible: When evaluating these compounds in a clinical trial, multiple outcomes are possible:
\begin{enumerate} \begin{enumerate}
\item The compound demonstrates sufficient safety and efficacy, and proceeds in the appoval process. \ref{Item:EndSuccess} \item The compound demonstrates sufficient safety and efficacy, and proceeds in the appoval process.
\item The compound fails to demonstrate sufficient safety and efficacy, and the approval process halts. \ref{Item:EndFail} \label{Item:EndSuccess}
\item The trial is terminated before it can acheive one of the first two outcomes, for reasons unrelated to safety and efficacy concerns. \label{Item:Terminate} \item The compound fails to demonstrate sufficient safety and efficacy, and the approval process halts.
\label{Item:EndFail}
\item The trial is terminated before it can acheive one of the first two
outcomes, for reasons unrelated to safety and efficacy concerns.
\label{Item:Terminate}
\end{enumerate} \end{enumerate}
\begin{table} \begin{table}
\caption{}\label{tab:} \caption{Potential States of Knowledge from a clinical trial}\label{tab:StatesOfKnowledge}
\begin{center} \begin{center}
\begin{tabular}{p{0.4\textwidth}|p{0.3\textwidth}|p{0.3\textwidth}|} \begin{tabular}{p{0.15\textwidth} p{0.2\textwidth}||p{0.25\textwidth}|p{0.25\textwidth}|}
\cline{2-3} \cline{3-4}
\multirow{2}{*}{} & \multicolumn{2}{c|}{Drug-Indication Match} \\ \multicolumn{2}{c|}{Drug-Indication Match} & safe and efficacious & not safe or not efficatious \\
\cline{2-3} \hline
& safe and efficacious & not safe nor efficatious \\
\hline \hline
\multirow{2}{*}{Discovery process} & Known good & Known bad \\ \multirow{2}{0.15\textwidth}{Operations} & Success & Known good & Known bad \\
\cline{2-3} \cline{2-4}
& Unknown & Unkown \\ & Failure & \multicolumn{2}{c|}{Unkown} \\
\cline{2-3} \cline{2-4}
\end{tabular} \end{tabular}
\end{center} \end{center}
\end{table} \end{table}
\begin{table}
\caption{Clinical Trial end states}\label{tab:ClinicalTrialEndStates}
\begin{center}
\begin{tabular}{p{0.15\textwidth} p{0.2\textwidth}||p{0.25\textwidth}|p{0.25\textwidth}|}
\cline{3-4}
\multicolumn{2}{c|}{Drug-Indication Match} & safe and efficacious & not safe or not efficatious \\
\hline
\hline
\multirow{2}{0.15\textwidth}{Operations} & Success & Completion & Completion or Termination \\
\cline{2-4}
& Failure & \multicolumn{2}{c|}{Termination} \\
\cline{2-4}
\end{tabular}
\end{center}
\end{table}
While it is known that pharmaceutical companies withdraw some drugs from While it is known that pharmaceutical companies withdraw some drugs from
their development pipeline due to commercialization concerns their development pipeline due to commercialization concerns
( (

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