diff --git a/Latex/Paper/sections/01_introduction.tex b/Latex/Paper/sections/01_introduction.tex index b01c214..2241ca2 100644 --- a/Latex/Paper/sections/01_introduction.tex +++ b/Latex/Paper/sections/01_introduction.tex @@ -16,31 +16,51 @@ are common One essential step to introduce a novel pharmaceutical - or even to begin selling a generic compound - is to establish that the drug as packaged and sold will have acceptable safety and efficacy profiles. -When evaluating these compounds in a clinical trial, both outcomes are possible: +When evaluating these compounds in a clinical trial, multiple outcomes are possible: \begin{enumerate} - \item The compound demonstrates sufficient safety and efficacy, and proceeds in the appoval process. \ref{Item:EndSuccess} - \item The compound fails to demonstrate sufficient safety and efficacy, and the approval process halts. \ref{Item:EndFail} - \item The trial is terminated before it can acheive one of the first two outcomes, for reasons unrelated to safety and efficacy concerns. \label{Item:Terminate} + \item The compound demonstrates sufficient safety and efficacy, and proceeds in the appoval process. + \label{Item:EndSuccess} + \item The compound fails to demonstrate sufficient safety and efficacy, and the approval process halts. + \label{Item:EndFail} + \item The trial is terminated before it can acheive one of the first two + outcomes, for reasons unrelated to safety and efficacy concerns. + \label{Item:Terminate} \end{enumerate} + \begin{table} - \caption{}\label{tab:} + \caption{Potential States of Knowledge from a clinical trial}\label{tab:StatesOfKnowledge} \begin{center} - \begin{tabular}{p{0.4\textwidth}|p{0.3\textwidth}|p{0.3\textwidth}|} - \cline{2-3} - \multirow{2}{*}{} & \multicolumn{2}{c|}{Drug-Indication Match} \\ - \cline{2-3} - & safe and efficacious & not safe nor efficatious \\ + \begin{tabular}{p{0.15\textwidth} p{0.2\textwidth}||p{0.25\textwidth}|p{0.25\textwidth}|} + \cline{3-4} + \multicolumn{2}{c|}{Drug-Indication Match} & safe and efficacious & not safe or not efficatious \\ + \hline \hline - \multirow{2}{*}{Discovery process} & Known good & Known bad \\ - \cline{2-3} - & Unknown & Unkown \\ - \cline{2-3} + \multirow{2}{0.15\textwidth}{Operations} & Success & Known good & Known bad \\ + \cline{2-4} + & Failure & \multicolumn{2}{c|}{Unkown} \\ + \cline{2-4} \end{tabular} \end{center} \end{table} +\begin{table} + \caption{Clinical Trial end states}\label{tab:ClinicalTrialEndStates} + \begin{center} + \begin{tabular}{p{0.15\textwidth} p{0.2\textwidth}||p{0.25\textwidth}|p{0.25\textwidth}|} + \cline{3-4} + \multicolumn{2}{c|}{Drug-Indication Match} & safe and efficacious & not safe or not efficatious \\ + \hline + \hline + \multirow{2}{0.15\textwidth}{Operations} & Success & Completion & Completion or Termination \\ + \cline{2-4} + & Failure & \multicolumn{2}{c|}{Termination} \\ + \cline{2-4} + \end{tabular} + \end{center} +\end{table} + While it is known that pharmaceutical companies withdraw some drugs from their development pipeline due to commercialization concerns (