added tables and references to intro

claude_rewrite
Will King 2 years ago
parent e5e052db35
commit 2fc6f08086

@ -16,31 +16,51 @@ are common
One essential step to introduce a novel pharmaceutical - or even
to begin selling a generic compound - is to establish that the drug as packaged and sold will
have acceptable safety and efficacy profiles.
When evaluating these compounds in a clinical trial, both outcomes are possible:
When evaluating these compounds in a clinical trial, multiple outcomes are possible:
\begin{enumerate}
\item The compound demonstrates sufficient safety and efficacy, and proceeds in the appoval process. \ref{Item:EndSuccess}
\item The compound fails to demonstrate sufficient safety and efficacy, and the approval process halts. \ref{Item:EndFail}
\item The trial is terminated before it can acheive one of the first two outcomes, for reasons unrelated to safety and efficacy concerns. \label{Item:Terminate}
\item The compound demonstrates sufficient safety and efficacy, and proceeds in the appoval process.
\label{Item:EndSuccess}
\item The compound fails to demonstrate sufficient safety and efficacy, and the approval process halts.
\label{Item:EndFail}
\item The trial is terminated before it can acheive one of the first two
outcomes, for reasons unrelated to safety and efficacy concerns.
\label{Item:Terminate}
\end{enumerate}
\begin{table}
\caption{}\label{tab:}
\caption{Potential States of Knowledge from a clinical trial}\label{tab:StatesOfKnowledge}
\begin{center}
\begin{tabular}{p{0.4\textwidth}|p{0.3\textwidth}|p{0.3\textwidth}|}
\cline{2-3}
\multirow{2}{*}{} & \multicolumn{2}{c|}{Drug-Indication Match} \\
\cline{2-3}
& safe and efficacious & not safe nor efficatious \\
\begin{tabular}{p{0.15\textwidth} p{0.2\textwidth}||p{0.25\textwidth}|p{0.25\textwidth}|}
\cline{3-4}
\multicolumn{2}{c|}{Drug-Indication Match} & safe and efficacious & not safe or not efficatious \\
\hline
\hline
\multirow{2}{*}{Discovery process} & Known good & Known bad \\
\cline{2-3}
& Unknown & Unkown \\
\cline{2-3}
\multirow{2}{0.15\textwidth}{Operations} & Success & Known good & Known bad \\
\cline{2-4}
& Failure & \multicolumn{2}{c|}{Unkown} \\
\cline{2-4}
\end{tabular}
\end{center}
\end{table}
\begin{table}
\caption{Clinical Trial end states}\label{tab:ClinicalTrialEndStates}
\begin{center}
\begin{tabular}{p{0.15\textwidth} p{0.2\textwidth}||p{0.25\textwidth}|p{0.25\textwidth}|}
\cline{3-4}
\multicolumn{2}{c|}{Drug-Indication Match} & safe and efficacious & not safe or not efficatious \\
\hline
\hline
\multirow{2}{0.15\textwidth}{Operations} & Success & Completion & Completion or Termination \\
\cline{2-4}
& Failure & \multicolumn{2}{c|}{Termination} \\
\cline{2-4}
\end{tabular}
\end{center}
\end{table}
While it is known that pharmaceutical companies withdraw some drugs from
their development pipeline due to commercialization concerns
(

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