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ClinicalTrialsPaper/Latex/assets/tikzit/CausalGraph.tikz

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\begin{tikzpicture}
\begin{pgfonlayer}{nodelayer}
\node [style=emptyBox] (0) at (-18.5, 4) {Compound Safety};
\node [style=emptyBox] (1) at (-18.5, -3.5) {Compound Effectiveness};
\node [style=emptyBox] (2) at (5, 0.75) {Population Size};
\node [style=Red Box] (3) at (-3.75, -3.5) {\begin{tabular}{l} Conclusion \\ $\bullet$ Status\\ $\bullet$ Duration \\ $\bullet$ Enrollment \end{tabular}};
\node [style=Red Box] (4) at (-3.75, 1) {Snapshot Enrollment};
\node [style=Red Box] (5) at (3.25, -2) {Market Conditions};
\node [style=Box] (6) at (-17.5, -5.5) {Sponsor Changes};
\node [style=Box] (7) at (-15.25, 0.25) {\begin{tabular}{l}Prior \\ Trials \end{tabular}};
\node [style=emptyBox] (8) at (-2.25, 4) {Beliefs about Compound};
\node [style=Box] (9) at (-10.75, 4) {Adverse Events};
\node [style=emptyBox] (10) at (3.25, -5.25) {Unobserved};
\node [style=Box] (11) at (3.25, -6.25) {Observed: Control};
\node [style=Red Box] (12) at (3.25, -7.25) {Observed: Of interest};
\node [style=emptyBox] (13) at (-10.75, 5.25) {Adverse Events};
\end{pgfonlayer}
\begin{pgfonlayer}{edgelayer}
\draw [style=RightArrow] (4) to (3);
\draw [style=RightArrow] (5) to (3);
\draw [style=Light Arrow] (2) to (5);
\draw [style=Light Arrow] (2) to (4);
\draw [style=Light Arrow] (5) to (4);
\draw [style=Light Arrow] (0) to (7);
\draw [style=Light Arrow] (1) to (7);
\draw [style=Light Arrow] (7) to (8);
\draw [style=Light Arrow] (8) to (4);
\draw [style=Light Arrow] (1) to (3);
\draw [style=Light Arrow] (6) to (3);
\draw [style=Light Arrow] (0) to (9);
\draw [style=Light Arrow] (9) to (3);
\end{pgfonlayer}
\end{tikzpicture}