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		\node [style=emptyBox] (2) at (5, 0.75) {Population Size};
		\node [style=Red Box] (3) at (-3.75, -3.5) {\begin{tabular}{l} Conclusion \\ $\bullet$ Status\\  $\bullet$ Duration \\ $\bullet$ Enrollment \end{tabular}};
		\node [style=Red Box] (4) at (-3.75, 1) {Snapshot Enrollment};
		\node [style=Red Box] (5) at (3.25, -2) {Market Conditions};
		\node [style=Box] (6) at (-17.5, -5.5) {Sponsor Changes};
		\node [style=Box] (7) at (-15.25, 0.25) {\begin{tabular}{l}Prior \\ Trials \end{tabular}};
		\node [style=emptyBox] (8) at (-2.25, 4) {Beliefs about Compound};
		\node [style=Box] (9) at (-10.75, 4) {Adverse Events};
		\node [style=emptyBox] (10) at (3.25, -5.25) {Unobserved};
		\node [style=Box] (11) at (3.25, -6.25) {Observed: Control};
		\node [style=Red Box] (12) at (3.25, -7.25) {Observed: Of interest};
		\node [style=emptyBox] (13) at (-10.75, 5.25) {Adverse Events};
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