Updated to what I am using so far

llm-extraction
will king 3 years ago
parent c4b8484cab
commit 256177e569

@ -21,13 +21,17 @@
"name": "aact_db",
"save-password": true,
"configuration": {
"host": "will-office",
"host": "100.95.169.11",
"port": "5432",
"database": "aact_db",
"url": "jdbc:postgresql://will-office:5432/aact_db",
"url": "jdbc:postgresql://100.95.169.11:5432/aact_db",
"configurationType": "MANUAL",
"type": "dev",
"provider-properties": {},
"auth-model": "native"
},
"custom-properties": {
"resultset.maxrows": "500"
}
},
"postgres-jdbc-186cd8f479f-6cc3c10c8adc3359": {
@ -42,7 +46,6 @@
"url": "jdbc:postgresql://localhost:54320/postgres",
"configurationType": "MANUAL",
"type": "dev",
"provider-properties": {},
"auth-model": "native"
}
}

@ -1 +1 @@
{"resources":{"Scripts/DiseaseBurdens_create_table.sql":{"default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db","default-schema":"public"},"Scripts/GlobalBurdensOfDisease2019Codebook.sql":{"default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db","default-schema":"DiseaseBurden"},"development_sql/ASSOICATING NCTIDs to NDCs and Marketing dates.sql":{"default-schema":"public","default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db"}}}
{"resources":{"Scripts/ASSOICATING NCTIDs to NDCs and Marketing dates.sql":{"default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db","default-schema":"public"},"Scripts/Data_summaries.sql":{"default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db","default-schema":"public"},"Scripts/DevelopingLinks.sql":{"default-schema":"public","default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db"},"Scripts/DiseaseBurdens_create_table.sql":{"default-schema":"public","default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db"},"Scripts/GlobalBurdensOfDisease2019Codebook.sql":{"default-schema":"DiseaseBurden","default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db"},"Scripts/GroupingTrials.sql":{"default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db","default-schema":"public"},"Scripts/Script.sql":{"default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db","default-schema":"public"},"Scripts/TablesAndViews_Public.sql":{"default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db","default-schema":"public"},"development_sql/ASSOICATING NCTIDs to NDCs and Marketing dates.sql":{"default-schema":"public","default-datasource":"postgres-jdbc-186c896a347-2a3d946d2dea4df7","default-catalog":"aact_db"}}}

@ -16,8 +16,8 @@ SELECT
bi.nct_id ,
bi.downcase_mesh_term,
rr.tty2 ,
rr.rxcui2 as bn_or_in_cui --brand or ingredient
,count(*)
rr.rxcui2 as bn_or_in_cui, --brand or ingredient
count(*)
FROM ctgov.browse_interventions bi
left outer JOIN rxnorm_migrated.rxnorm_props AS rp
on bi.downcase_mesh_term = rp.propvalue1 --link names to drug cuis ()
@ -123,4 +123,11 @@ group by mttn.nct_id,n.application_number_or_citation
order by mttn.nct_id
;
---Number of trials after a certain date
select nct_id,count(distinct application_number_or_citation)
from public.match_trial_to_marketing_start_date mttmsd
where "min" > '2012-06-01'
group by nct_id
;

@ -17,11 +17,12 @@ group by status;
/* Get a list of trials
* -- There are currently 304 trials for which I was able to extract unique snapshots (2023-03-29)
* -- There are currently 1138 trials for which I was able to extract unique snapshots (2023-04-03)
* */
select count(distinct nct_id) from history.trial_snapshots ts
/* Get the number of listed conditions
* -- There are only 609 listed (MeSH classified) conditions from 284 trials
* -- There are only 609 listed (MeSH classified) conditions from 284 trials(2023-03-29)
* I may need to expand how I address conditions
*/
select count(*)
@ -60,5 +61,40 @@ nct_id in (select distinct nct_id from history.trial_snapshots ts)
*/
select count(*) from "DiseaseBurden".trial_to_icd10 tti ;
--1383 before run at 8pm 2023-03-29
--5209 at 2023-04-03T11:21
/*Get the number of trials that have links to icd10 trials*/
select tti.approved,count(distinct nct_id) from "DiseaseBurden".trial_to_icd10 tti
group by tti.approved;
-- finding and removing duplicates from the trial linking stuff. Useful when you redownload trials.
/*
with CTE as (
select row_number() over (partition by nct_id, "condition",ui) as rownum, *
from "DiseaseBurden".trial_to_icd10 tti
)
delete from "DiseaseBurden".trial_to_icd10 tti2
where id in (
select id from cte where rownum > 1
);
*/
--get the number of completed vs terminated trials
select overall_status,count(distinct nct_id)
from ctgov.studies s
where nct_id in (select distinct nct_id from "DiseaseBurden".trial_to_icd10 tti where tti.approved ='accepted' )
group by overall_status
;
select overall_status,count(distinct nct_id)
from ctgov.studies s
where nct_id in (select distinct nct_id from "DiseaseBurden".trial_to_icd10 tti)
group by overall_status
;
select overall_status,count(distinct nct_id)
from ctgov.studies s
where nct_id in (select distinct nct_id from history.trial_snapshots ts )
group by overall_status
;

@ -1,3 +1,5 @@
--TODO: Document and migrate to setup
drop table if exists "DiseaseBurden".trial_to_icd10;
drop type if exists "DiseaseBurden".validation_type;

@ -0,0 +1,636 @@
create extension tablefunc;
/*Getting Trial Data all together
* There are 3 main datasets to join per trial:
*
* - Trial Data (still need to stick it together)
* - Duration and enrollment data
* - Compound Marketing (can get for any trial)
* - how many individual brands per compound at the start of the trial
* - Disease Data (can get for verified trials)
* - Population upper limit (Global Burdens of Disease)
* - Category (ICD10 2nd level groups)
*/
/*Disease Data*/
-- ICD10 Category and GBD data
with cte as (
select
nct_id,
max("level") as max_level
from trial_to_cause
group by nct_id
), cte2 as (
select
ttc.nct_id,
ttc.ui,
ttc."condition",
ttc.cause_text,
ttc.cause_id,
cte.max_level
from trial_to_cause ttc
join cte
on cte.nct_id=ttc.nct_id
where ttc."level"=cte.max_level
group by
ttc.nct_id,
ttc.ui,
ttc."condition",
ttc.cause_text,
ttc.cause_id,
cte.max_level
order by nct_id,ui
), cte3 as (
select
nct_id,
substring(cte2.ui for 3) as code,
cte2."condition",
cte2.cause_text,
cte2.cause_id,
ic.id as category_id,
ic.group_name
from cte2
join "DiseaseBurden".icd10_categories ic
on
substring(cte2.ui for 3) <= ic.end_code
and
substring(cte2.ui for 3) >= ic.start_code
)
select nct_id, cause_id,category_id
from cte3
group by nct_id, cause_id, category_id
;
--still need to link to actual disease burdens.
/*Compound Marketing Data*/
---Number of trials after a certain date
with marketing_cte as (
select nct_id,count(distinct application_number_or_citation)
from public.match_trial_to_marketing_start_date mttmsd
where "min" > '2012-06-01'
group by nct_id
)
select * from marketing_cte
;
/*Get versions*/
/* Ignore this version
with cte1 as (
select nct_id,min("version") over (partition by nct_id) as min_version
from history.trial_snapshots ts
where
ts.start_date < ts.submission_date
), cte2 as (
select * from cte1
group by nct_id, min_version
order by nct_id
), cte3 as (
select
ts2.nct_id,
ts2."version",
ts2.overall_status,
ts2.submission_date,
ts2.start_date,
ts2.enrollment,
ts2.enrollment_category,
ts2.primary_completion_date,
ts2.primary_completion_date_category ,
--mv.nct_id,
mv.min_version
from history.trial_snapshots ts2
join cte2 mv
on mv.nct_id = ts2.nct_id
where
ts2."version" = mv.min_version
order by ts2.nct_id
), cte4 as (
select cte3.nct_id, cte3.submission_date - cte3.start_date as submission_presecence
from cte3
)
select avg(submission_presecence)
from cte4
;
--avg 61 day difference
*/
--use this version
with cte1 as ( --get trials
select nct_id,max("version") over (partition by nct_id) as min_version
from history.trial_snapshots ts
where
ts.start_date > ts.submission_date
), cte2 as ( --
select * from cte1
group by nct_id, min_version
order by nct_id
), cte3 as (
select
ts2.nct_id,
ts2."version",
ts2.overall_status,
ts2.submission_date,
ts2.start_date,
ts2.enrollment,
ts2.enrollment_category,
ts2.primary_completion_date,
ts2.primary_completion_date_category ,
--mv.nct_id,
mv.min_version
from history.trial_snapshots ts2
join cte2 mv
on mv.nct_id = ts2.nct_id
where
ts2."version" = mv.min_version
order by ts2.nct_id
)
select *
from cte3
where
enrollment is null
or enrollment_category is null
or primary_completion_date is null
or primary_completion_date_category is null
or start_date is null
/*, cte4 as (
select cte3.nct_id, cte3.submission_date - cte3.start_date as submission_presecence
from cte3
)
select avg(submission_presecence)
from cte4
; -- -33 day difference on average
*/
with cte1_min as (
select nct_id,min("version") over (partition by nct_id) as min_version
from history.trial_snapshots ts
where
ts.start_date <= ts.submission_date
),cte1_max as (
select nct_id,max("version") over (partition by nct_id) as max_version
from history.trial_snapshots ts
where
ts.start_date >= ts.submission_date
), cte2_min as (
select * from cte1_min
group by nct_id, min_version
), cte2_max as (
select * from cte1_max
group by nct_id, max_version
)
select *
from cte2_min
join cte2_max
on cte2_min.nct_id=cte2_max.nct_id
where min_version >= max_version
/* Neet to take a different tack in filling out the is version of the data.
* The idea is that we need the latest of each major category
* before the start date.
* */
--get the set of trials which have
with cte as (
/* Get the absolute difference between the start date and the
* submission_date for each version of the trial (measured in days)
*
*/
select
s.nct_id,
s.start_date,
ts."version",
ts.submission_date,
abs(extract(epoch from ts.submission_date - s.start_date)::float/(24*60*60)) as start_deviance
from ctgov.studies s
join history.trial_snapshots ts
on s.nct_id = ts.nct_id
where s.nct_id in (select distinct nct_id from "DiseaseBurden".trial_to_icd10 tti)
),cte2 as (
/* Rank each version based on it's proximity to the start date
* */
select
cte.nct_id,
cte."version",
row_number() over (partition by cte.nct_id order by cte.start_deviance) as rownum,
cte.submission_date,
cte.start_deviance,
cte.start_date,
ts.primary_completion_date ,
ts.primary_completion_date_category ,
ts.overall_status ,
ts.enrollment ,
ts.enrollment_category
from cte
join history.trial_snapshots ts
on cte.nct_id=ts.nct_id and cte."version"=ts."version"
), cte3_primary_completion as (
/* for each trial
* select the version with a filled out primary_completion_source
* that is closest to the start date.
* */
select cte2.nct_id, min(cte2.rownum) as primary_completion_source
from cte2
where cte2.primary_completion_date is not null
group by cte2.nct_id
), cte3_enrollment as (
/* for each trial
* select the version with a filled out enrollment
* that is closest to the start date.
* */
select cte2.nct_id, min(cte2.rownum) as enrollment_source
from cte2
where cte2.enrollment is not null
group by cte2.nct_id
), cte4 as (
/* join the best options together to get the data of interest.
*
* On further inspection there are just a view of those, with
* many of them having a 7+ month difference between the two versions.
* I think I am going to drop them.
* */
select
c3e.nct_id,
--c2a.submission_date as submission_date_a,
--c2b.submission_date as submission_date_b,
--c3e.enrollment_source,
c2a."version" as version_a,
c2a.enrollment,
c2a.enrollment_category,
--c3p.primary_completion_source ,
c2b."version" as version_b,
c2b.primary_completion_date,
c2b.primary_completion_date_category
from cte3_enrollment c3e
join cte2 c2a
on c3e.nct_id = c2a.nct_id and c3e.enrollment_source = c2a.rownum
join cte3_primary_completion c3p
on c3e.nct_id = c3p.nct_id
join cte2 c2b
on c3p.nct_id=c2b.nct_id and c3p.primary_completion_source = c2b.rownum
), cte5 as (
select nct_id
from cte4 where version_a != version_b
)
select
c.nct_id,
s2.overall_status,
c.enrollment as planned_enrollment,
s2.enrollment,
s2.start_date,
c.primary_completion_date as planned_primary_completion_date,
s2.primary_completion_date,
extract(epoch from c.primary_completion_date - s2.start_date)/(24*60*60) as planned_duration,
s2.primary_completion_date - s2.start_date as actual_duration
from cte4 c
join ctgov.studies s2
on c.nct_id = s2.nct_id
where c.nct_id not in (select nct_id from cte5)
;
/*
* Concern about causal inference
*
* When putting the data together for CBO it looked like we got occasional updates about
* the status of trials that included enrollment updates.
* That doesn't appear to be the case, but that messes with the ability to causally identify
* any results. I need to be careful about this data is used.
*
* I created the statements below to get the data that I need.
*/
----get the set of trial snapshots
create or replace view public.view_cte as
select
nct_id,
primary_completion_date,
primary_completion_date_category,
enrollment,
start_date,
enrollment_category ,
overall_status,
--count("version"),
min(submission_date) as earliest_date_observed
from history.trial_snapshots ts
where
nct_id in (select distinct nct_id from "DiseaseBurden".trial_to_icd10 tti where tti.approved='accepted')
and submission_date >= start_date
and overall_status not in ('Completed','Terminated')
group by
nct_id,
primary_completion_date,
primary_completion_date_category,
start_date,
enrollment,
enrollment_category ,
overall_status
;
create or replace view public.view_disbur_cte0 as
select tti.nct_id, tti.ui , tti."condition",itc.cause_text, ch.cause_id, ch."level"
from "DiseaseBurden".trial_to_icd10 tti
join "DiseaseBurden".icd10_to_cause itc
on replace(REPLACE(tti.ui,'-',''),'.','') = replace(REPLACE(itc.code ,'-',''),'.','')
join "DiseaseBurden".cause_hierarchy ch
on itc.cause_text = ch.cause_name
where
tti.approved = 'accepted'
;
create or replace view public.view_trial_to_cause as
select tti.nct_id, tti.ui , tti."condition",itc.cause_text, ch.cause_id, ch."level"
from "DiseaseBurden".trial_to_icd10 tti
join "DiseaseBurden".icd10_to_cause itc
on replace(REPLACE(tti.ui,'-',''),'.','') = replace(REPLACE(itc.code ,'-',''),'.','')
join "DiseaseBurden".cause_hierarchy ch
on itc.cause_text = ch.cause_name
where
tti.approved = 'accepted'
order by nct_id
;--does this duplicate the view above?
create or replace view public.view_disbur_cte as
select
nct_id,
max("level") as max_level
from view_disbur_cte0
group by nct_id
;
create or replace view public.view_disbur_cte2 as
select
ttc.nct_id,
ttc.ui,
ttc."condition",
ttc.cause_text,
ttc.cause_id,
disbur_cte.max_level
from view_trial_to_cause ttc
join view_disbur_cte as disbur_cte
on disbur_cte.nct_id=ttc.nct_id
where ttc."level"=disbur_cte.max_level
group by
ttc.nct_id,
ttc.ui,
ttc."condition",
ttc.cause_text,
ttc.cause_id,
disbur_cte.max_level
order by nct_id,ui
;
create or replace view public.view_disbur_cte3 as
select
nct_id,
substring(disbur_cte2.ui for 3) as code,
disbur_cte2."condition",
disbur_cte2.cause_text,
disbur_cte2.cause_id,
ic.chapter_code as category_id,
ic.group_name,
disbur_cte2.max_level
from view_disbur_cte2 as disbur_cte2
join "DiseaseBurden".icd10_categories ic
on
substring(disbur_cte2.ui for 3) <= ic.end_code
and
substring(disbur_cte2.ui for 3) >= ic.start_code
where ic."level" = 1
;
create or replace view public.view_burdens_cte as
select *
from "DiseaseBurden".burdens b
where b.sex_id = 3 --both sexes
and b.metric_id = 1 --number/count
and b.measure_id = 2 --DALYs
and b.age_id =22 --all ages
;
create or replace view public.view_burdens_cte2 as
select
--c1.location_id,
c1.cause_id,
c1."year",
--high sdi
c1.val as h_sdi_val,
c1.upper_95 as h_sdi_u95,
c1.lower_95 as h_sdi_l95,
--high-middle sdi
c2.val as hm_sdi_val,
c2.upper_95 as hm_sdi_u95,
c2.lower_95 as hm_sdi_l95,
--middle sdi
c3.val as m_sdi_val,
c3.upper_95 as m_sdi_u95,
c3.lower_95 as m_sdi_l95,
--low-middle sdi
c4.val as lm_sdi_val,
c4.upper_95 as lm_sdi_u95,
c4.lower_95 as lm_sdi_l95,
--low sdi
c5.val as l_sdi_val,
c5.upper_95 as l_sdi_u95,
c5.lower_95 as l_sdi_l95
from view_burdens_cte c1
join view_burdens_cte c2
on c1.cause_id = c2.cause_id
and c1."year" = c2."year"
join view_burdens_cte c3
on c1.cause_id = c3.cause_id
and c1."year" = c3."year"
join view_burdens_cte c4
on c1.cause_id = c4.cause_id
and c1."year" = c4."year"
join view_burdens_cte c5
on c1.cause_id = c5.cause_id
and c1."year" = c5."year"
where c1.location_id = 44635
and c2.location_id = 44634
and c3.location_id = 44639
and c4.location_id = 44636
and c5.location_id = 44637
;
--drop view if exists public.formatted_data cascade;
create or replace view public.formatted_data as
select
cte.nct_id,
cte.start_date,
cte.enrollment as current_enrollment,
cte.enrollment_category,
cte.overall_status as current_status,
cte.earliest_date_observed,
extract( epoch from (cte.earliest_date_observed - cte.start_date))/extract( epoch from (cte.primary_completion_date - cte.start_date)) as elapsed_duration
,count(distinct mttmsd."application_number_or_citation") as n_brands
,dbc3.code
,dbc3."condition"
,dbc3.cause_text
,dbc3.cause_id
,dbc3.category_id
,dbc3.group_name
,dbc3.max_level
--c1.location_id,
--,b.cause_id
,b."year",
--high sdi
b.h_sdi_val,
b.h_sdi_u95,
b.h_sdi_l95,
--high-middle sdi
b.hm_sdi_val,
b.hm_sdi_u95,
b.hm_sdi_l95,
--middle sdi
b.m_sdi_val,
b.m_sdi_u95,
b.m_sdi_l95,
--low-middle sdi
b.lm_sdi_val,
b.lm_sdi_u95,
b.lm_sdi_l95,
--low sdi
b.l_sdi_val,
b.l_sdi_u95,
b.l_sdi_l95
from view_cte as cte
join public.match_trial_to_marketing_start_date mttmsd
on cte.nct_id = mttmsd."nct_id"
join view_disbur_cte3 dbc3
on dbc3.nct_id = cte.nct_id
join view_burdens_cte2 b
on b.cause_id = dbc3.cause_id and extract(year from b."year") = extract(year from cte.earliest_date_observed)
where
mttmsd."min" <= cte.earliest_date_observed
group by
cte.nct_id,
cte.start_date,
cte.enrollment,
cte.enrollment_category,
cte.overall_status,
cte.earliest_date_observed,
elapsed_duration
,dbc3.code
,dbc3."condition"
,dbc3.cause_text
,dbc3.cause_id
,dbc3.category_id
,dbc3.group_name
,dbc3.max_level
--c1.location_id,
,b.cause_id,
b."year",
--high sdi
b.h_sdi_val,
b.h_sdi_u95,
b.h_sdi_l95,
--high-middle sdi
b.hm_sdi_val,
b.hm_sdi_u95,
b.hm_sdi_l95,
--middle sdi
b.m_sdi_val,
b.m_sdi_u95,
b.m_sdi_l95,
--low-middle sdi
b.lm_sdi_val,
b.lm_sdi_u95,
b.lm_sdi_l95,
--low sdi
b.l_sdi_val,
b.l_sdi_u95,
b.l_sdi_l95
order by cte.nct_id ,cte.earliest_date_observed
;--used this one 2023-04-05
--get the planned enrollment
create or replace view public.time_between_submission_and_start_view as
/* Get the absolute difference between the start date and the
* submission_date for each version of the trial (measured in days)
*
*/
select
s.nct_id,
s.start_date,
ts."version",
ts.submission_date,
abs(extract(epoch from ts.submission_date - s.start_date)::float/(24*60*60)) as start_deviance
from ctgov.studies s
join history.trial_snapshots ts
on s.nct_id = ts.nct_id
where s.nct_id in (select distinct nct_id from "DiseaseBurden".trial_to_icd10 tti)
;
create or replace view rank_proximity_to_start_time_view as
/* Rank each version based on it's proximity to the start date
* */
select
cte.nct_id,
cte."version",
row_number() over (partition by cte.nct_id order by cte.start_deviance) as rownum,
cte.submission_date,
cte.start_deviance,
cte.start_date,
ts.primary_completion_date ,
ts.primary_completion_date_category ,
ts.overall_status ,
ts.enrollment ,
ts.enrollment_category
from public.time_between_submission_and_start_view cte
join history.trial_snapshots ts
on cte.nct_id=ts.nct_id and cte."version"=ts."version"
;
create or replace view enrollment_closest_to_start_view as
/* for each trial
* select the version with a filled out enrollment
* that is closest to the start date.
* */
select cte2.nct_id, min(cte2.rownum) as enrollment_source
from rank_proximity_to_start_time_view cte2
where cte2.enrollment is not null
group by cte2.nct_id
;
--drop view public.formatted_data_with_planned_enrollment ;
create or replace view formatted_data_with_planned_enrollment as
select
f.*,
s.overall_status as final_status,
c2a."version",
c2a.enrollment as planned_enrollment
from formatted_data f
join ctgov.studies s
on f.nct_id = s.nct_id
join enrollment_closest_to_start_view c3e
on c3e.nct_id = f.nct_id
join rank_proximity_to_start_time_view c2a
on c3e.nct_id = c2a.nct_id and c3e.enrollment_source = c2a.rownum
;
select * from formatted_data_with_planned_enrollment
-------------------GET COUNTS------------------
select count(distinct nct_id) from public.view_cte; --88
select count(distinct nct_id) from public.view_disbur_cte0; --130
select count(distinct nct_id) from public.view_trial_to_cause; --130
select count(distinct nct_id) from public.view_disbur_cte;--130
select count(distinct nct_id) from public.view_disbur_cte2;--130
select count(distinct nct_id) from public.view_disbur_cte3;--130
select count(distinct nct_id) from public.formatted_data; --48 probably because there are so many trials that don't fall into a GBD category/cause
select count(distinct nct_id) from public.time_between_submission_and_start_view;--1067
select count(distinct nct_id) from rank_proximity_to_start_time_view;--1067
select count(distinct nct_id) from enrollment_closest_to_start_view;--1067
select count(distinct nct_id) from formatted_data_with_planned_enrollment;--48

@ -1,6 +1,7 @@
select * from "DiseaseBurden".icd10_to_cause itc ;
select * from "DiseaseBurden".cause c ;
select
select c.id, count(distinct code)
@ -11,22 +12,93 @@ group by c.id
order by c.id
;
select count(distinct nct_id) from "DiseaseBurden".trial_to_icd10 tti
where tti.approved = 'accepted';
select tti.approved,count(distinct nct_id) from "DiseaseBurden".trial_to_icd10 tti
group by tti.approved;
select nct_id, "condition", ui
from "DiseaseBurden".trial_to_icd10 tti
where tti.approved = 'accepted';
drop view trial_to_cause;
---Link trials to their causes
select tti.nct_id, tti."condition",itc.cause_text
create temp view trial_to_cause as
select tti.nct_id, tti.ui , tti."condition",itc.cause_text, ch.cause_id, ch."level"
from "DiseaseBurden".trial_to_icd10 tti
join "DiseaseBurden".icd10_to_cause itc
on replace(REPLACE(tti.ui,'-',''),'.','') = replace(REPLACE(itc.code ,'-',''),'.','')
join "DiseaseBurden".cause_hierarchy ch
on itc.cause_text = ch.cause_name
where
tti.approved = 'accepted'
and
itc.cause_text not in ('Non-communicable diseases','Neoplasms','Mental disorders','Other non-communicable diseases')
group by tti.nct_id , tti."condition" , itc.cause_text
order by nct_id
;
;
select distinct nct_id, count(*), min("level"), max("level")
from trial_to_cause ttc
group by nct_id
;
select nct_id,cause_text,cause_id from trial_to_cause
where level = 3
group by nct_id,cause_text,cause_id
order by cause_id
;
select cause_id,"condition",cause_text,count(distinct nct_id) as c
from trial_to_cause
where level >= 3
group by cause_id,"condition",cause_text
--having count(distinct nct_id) > 2
order by cause_id
;
with cte as (
select
nct_id,
max("level") as max_level
from trial_to_cause
group by nct_id
), cte2 as (
select
ttc.nct_id,
ttc.ui,
ttc."condition",
ttc.cause_text,
ttc.cause_id,
cte.max_level
from trial_to_cause ttc
join cte
on cte.nct_id=ttc.nct_id
where ttc."level"=cte.max_level
group by
ttc.nct_id,
ttc.ui,
ttc."condition",
ttc.cause_text,
ttc.cause_id,
cte.max_level
order by nct_id,ui
), cte3 as (
select
nct_id,
substring(cte2.ui for 3) as code,
cte2."condition",
cte2.cause_text,
cte2.cause_id,
ic.id as category_id,
ic.group_name
from cte2
join "DiseaseBurden".icd10_categories ic
on
substring(cte2.ui for 3) <= ic.end_code
and
substring(cte2.ui for 3) >= ic.start_code
)
select nct_id, cause_id,category_id
from cte3
group by nct_id, cause_id, category_id
;

@ -0,0 +1,83 @@
drop view if exists public.match_trial_to_marketing_start_date;
DROP VIEW if exists public.match_trial_to_ndc11;
drop view if exists public.match_trials_to_bn_in;
drop view if exists history.match_drugs_to_trials;
DROP TABLE IF EXISTS history.trial_snapshots;
CREATE TABLE IF NOT EXISTS history.trial_snapshots
(
nct_id character varying(15) COLLATE pg_catalog."default" NOT NULL,
version integer NOT NULL,
submission_date timestamp without time zone,
primary_completion_date timestamp without time zone,
primary_completion_date_category history.updatable_catetories,
start_date timestamp without time zone,
start_date_category history.updatable_catetories,
completion_date timestamp without time zone,
completion_date_category history.updatable_catetories,
overall_status history.study_statuses,
enrollment integer,
enrollment_category history.updatable_catetories,
sponsor character varying COLLATE pg_catalog."default",
responsible_party character varying COLLATE pg_catalog."default",
CONSTRAINT trial_snapshots_pkey PRIMARY KEY (nct_id, version)
);
ALTER TABLE IF EXISTS history.trial_snapshots
OWNER to root;
CREATE OR REPLACE VIEW history.match_drugs_to_trials
AS SELECT bi.nct_id,
rp.rxcui,
rp.propvalue1
FROM ctgov.browse_interventions bi
JOIN rxnorm_migrated.rxnorm_props rp ON bi.downcase_mesh_term::text = rp.propvalue1::text
WHERE rp.propname::text = 'RxNorm Name'::text AND (bi.nct_id::text IN ( SELECT trial_snapshots.nct_id
FROM history.trial_snapshots));
CREATE OR REPLACE VIEW public.match_trials_to_bn_in
AS WITH trialncts AS (
SELECT DISTINCT ts.nct_id
FROM history.trial_snapshots ts
)
SELECT bi.nct_id,
bi.downcase_mesh_term,
rr.tty2,
rr.rxcui2 AS bn_or_in_cui,
count(*) AS count
FROM ctgov.browse_interventions bi
LEFT JOIN rxnorm_migrated.rxnorm_props rp ON bi.downcase_mesh_term::text = rp.propvalue1::text
LEFT JOIN rxnorm_migrated.rxnorm_relations rr ON rr.rxcui1 = rp.rxcui
WHERE (bi.nct_id::text IN ( SELECT trialncts.nct_id
FROM trialncts)) AND bi.mesh_type::text = 'mesh-list'::text AND rp.propname::text = 'Active_ingredient_name'::text AND (rr.tty2 = ANY (ARRAY['BN'::bpchar, 'IN'::bpchar, 'MIN'::bpchar]))
GROUP BY bi.nct_id, bi.downcase_mesh_term, rr.tty2, rr.rxcui2
ORDER BY bi.nct_id;
CREATE OR REPLACE VIEW public.match_trial_to_ndc11
AS SELECT mttbi.nct_id,
ah.ndc,
count(*) AS count
FROM match_trials_to_bn_in mttbi
LEFT JOIN rxnorm_migrated.rxnorm_relations rr ON mttbi.bn_or_in_cui = rr.rxcui1
LEFT JOIN rxnorm_migrated."ALLNDC_HISTORY" ah ON rr.rxcui2 = ah.rxcui
WHERE rr.tty1 = 'BN'::bpchar AND (rr.tty2 = ANY (ARRAY['SBD'::bpchar, 'BPCK'::bpchar])) AND ah.sab::text = 'RXNORM'::text
GROUP BY mttbi.nct_id, ah.ndc
ORDER BY mttbi.nct_id, ah.ndc;
CREATE OR REPLACE VIEW public.match_trial_to_marketing_start_date
AS SELECT mttn.nct_id,
n.application_number_or_citation,
min(n.marketing_start_date) AS min
FROM match_trial_to_ndc11 mttn
JOIN spl.nsde n ON mttn.ndc = n.package_ndc11::bpchar
WHERE n.product_type::text = 'HUMAN PRESCRIPTION DRUG'::text AND (n.marketing_category::text = ANY (ARRAY['NDA'::character varying, 'ANDA'::character varying, 'BLA'::character varying, 'NDA authorized generic'::character varying, 'NDA AUTHORIZED GENERIC'::character varying]::text[]))
GROUP BY mttn.nct_id, n.application_number_or_citation
ORDER BY mttn.nct_id;

@ -97,6 +97,7 @@ CREATE TABLE IF NOT EXISTS history.trial_snapshots
(
nct_id character varying(15) COLLATE pg_catalog."default" NOT NULL,
version integer NOT NULL,
submission_date timestamp NOT NULL,
primary_completion_date timestamp without time zone,
primary_completion_date_category history.updatable_catetories,
start_date timestamp without time zone,
@ -106,11 +107,21 @@ CREATE TABLE IF NOT EXISTS history.trial_snapshots
overall_status history.study_statuses,
enrollment integer,
enrollment_category history.updatable_catetories,
sponsor character varying(255) COLLATE pg_catalog."default",
responsible_party character varying(255) COLLATE pg_catalog."default",
sponsor character varying COLLATE pg_catalog."default",
responsible_party character varying COLLATE pg_catalog."default",
CONSTRAINT trial_snapshots_pkey PRIMARY KEY (nct_id, version)
);
ALTER TABLE IF EXISTS history.trial_snapshots
OWNER to root;
CREATE OR REPLACE VIEW history.match_drugs_to_trials
AS SELECT bi.nct_id,
rp.rxcui,
rp.propvalue1
FROM ctgov.browse_interventions bi
JOIN rxnorm_migrated.rxnorm_props rp ON bi.downcase_mesh_term::text = rp.propvalue1::text
WHERE rp.propname::text = 'RxNorm Name'::text AND (bi.nct_id::text IN ( SELECT trial_snapshots.nct_id
FROM history.trial_snapshots));

@ -0,0 +1,365 @@
Cause ID,Cause Name,Parent ID,Parent Name,Level,Cause Outline,Sort Order,YLL Only,YLD Only
294,All causes,294,All causes,0,Total,1,,
295,"Communicable, maternal, neonatal, and nutritional diseases",294,All causes,1,A,2,,
955,HIV/AIDS and sexually transmitted infections,295,"Communicable, maternal, neonatal, and nutritional diseases",2,A.1,3,,
298,HIV/AIDS,955,HIV/AIDS and sexually transmitted infections,3,A.1.1,4,,
948,HIV/AIDS - Drug-susceptible Tuberculosis,298,HIV/AIDS,4,A.1.1.1,5,,
949,HIV/AIDS - Multidrug-resistant Tuberculosis without extensive drug resistance,298,HIV/AIDS,4,A.1.1.2,6,,
950,HIV/AIDS - Extensively drug-resistant Tuberculosis,298,HIV/AIDS,4,A.1.1.3,7,,
300,HIV/AIDS resulting in other diseases,298,HIV/AIDS,4,A.1.1.4,8,,
393,Sexually transmitted infections excluding HIV,955,HIV/AIDS and sexually transmitted infections,3,A.1.2,9,,
394,Syphilis,393,Sexually transmitted infections excluding HIV,4,A.1.2.1,10,,
395,Chlamydial infection,393,Sexually transmitted infections excluding HIV,4,A.1.2.2,11,,
396,Gonococcal infection,393,Sexually transmitted infections excluding HIV,4,A.1.2.3,12,,
397,Trichomoniasis,393,Sexually transmitted infections excluding HIV,4,A.1.2.4,13,,X
398,Genital herpes,393,Sexually transmitted infections excluding HIV,4,A.1.2.5,14,,X
399,Other sexually transmitted infections,393,Sexually transmitted infections excluding HIV,4,A.1.2.6,15,,
956,Respiratory infections and tuberculosis,295,"Communicable, maternal, neonatal, and nutritional diseases",2,A.2,16,,
297,Tuberculosis,956,Respiratory infections and tuberculosis,3,A.2.1,17,,
954,Latent tuberculosis infection,297,Tuberculosis,4,A.2.1.1,18,,X
934,Drug-susceptible tuberculosis,297,Tuberculosis,4,A.2.1.2,19,,
946,Multidrug-resistant tuberculosis without extensive drug resistance,297,Tuberculosis,4,A.2.1.3,20,,
947,Extensively drug-resistant tuberculosis,297,Tuberculosis,4,A.2.1.4,21,,
322,Lower respiratory infections,956,Respiratory infections and tuberculosis,3,A.2.2,22,,
328,Upper respiratory infections,956,Respiratory infections and tuberculosis,3,A.2.3,23,,
329,Otitis media,956,Respiratory infections and tuberculosis,3,A.2.4,24,,
957,Enteric infections,295,"Communicable, maternal, neonatal, and nutritional diseases",2,A.3,25,,
302,Diarrheal diseases,957,Enteric infections,3,A.3.1,26,,
958,Typhoid and paratyphoid,957,Enteric infections,3,A.3.2,27,,
319,Typhoid fever,958,Typhoid and paratyphoid,4,A.3.2.1,28,,
320,Paratyphoid fever,958,Typhoid and paratyphoid,4,A.3.2.2,29,,
959,Invasive Non-typhoidal Salmonella (iNTS),957,Enteric infections,3,A.3.3,30,,
321,Other intestinal infectious diseases,957,Enteric infections,3,A.3.4,31,,
344,Neglected tropical diseases and malaria,295,"Communicable, maternal, neonatal, and nutritional diseases",2,A.4,32,,
345,Malaria,344,Neglected tropical diseases and malaria,3,A.4.1,33,,
346,Chagas disease,344,Neglected tropical diseases and malaria,3,A.4.2,34,,
347,Leishmaniasis,344,Neglected tropical diseases and malaria,3,A.4.3,35,,
348,Visceral leishmaniasis,347,Leishmaniasis,4,A.4.3.1,36,,
349,Cutaneous and mucocutaneous leishmaniasis,347,Leishmaniasis,4,A.4.3.2,37,,X
350,African trypanosomiasis,344,Neglected tropical diseases and malaria,3,A.4.4,38,,
351,Schistosomiasis,344,Neglected tropical diseases and malaria,3,A.4.5,39,,
352,Cysticercosis,344,Neglected tropical diseases and malaria,3,A.4.6,40,,
353,Cystic echinococcosis,344,Neglected tropical diseases and malaria,3,A.4.7,41,,
354,Lymphatic filariasis,344,Neglected tropical diseases and malaria,3,A.4.8,42,,X
355,Onchocerciasis,344,Neglected tropical diseases and malaria,3,A.4.9,43,,X
356,Trachoma,344,Neglected tropical diseases and malaria,3,A.4.10,44,,X
357,Dengue,344,Neglected tropical diseases and malaria,3,A.4.11,45,,
358,Yellow fever,344,Neglected tropical diseases and malaria,3,A.4.12,46,,
359,Rabies,344,Neglected tropical diseases and malaria,3,A.4.13,47,,
360,Intestinal nematode infections,344,Neglected tropical diseases and malaria,3,A.4.14,48,,
361,Ascariasis,360,Intestinal nematode infections,4,A.4.14.1,49,,
362,Trichuriasis,360,Intestinal nematode infections,4,A.4.14.2,50,,X
363,Hookworm disease,360,Intestinal nematode infections,4,A.4.14.3,51,,X
364,Food-borne trematodiases,344,Neglected tropical diseases and malaria,3,A.4.15,52,,X
405,Leprosy,344,Neglected tropical diseases and malaria,3,A.4.16,53,,X
843,Ebola,344,Neglected tropical diseases and malaria,3,A.4.17,54,,
935,Zika virus,344,Neglected tropical diseases and malaria,3,A.4.18,55,,
936,Guinea worm disease,344,Neglected tropical diseases and malaria,3,A.4.19,56,,X
365,Other neglected tropical diseases,344,Neglected tropical diseases and malaria,3,A.4.20,57,,
961,Other infectious diseases,295,"Communicable, maternal, neonatal, and nutritional diseases",2,A.5,58,,
332,Meningitis,961,Other infectious diseases,3,A.5.1,59,,
337,Encephalitis,961,Other infectious diseases,3,A.5.2,60,,
338,Diphtheria,961,Other infectious diseases,3,A.5.3,61,,
339,Whooping cough,961,Other infectious diseases,3,A.5.4,62,,
340,Tetanus,961,Other infectious diseases,3,A.5.5,63,,
341,Measles,961,Other infectious diseases,3,A.5.6,64,,
342,Varicella and herpes zoster,961,Other infectious diseases,3,A.5.7,65,,
400,Acute hepatitis,961,Other infectious diseases,3,A.5.8,66,,
401,Acute hepatitis A,400,Acute hepatitis,4,A.5.8.1,67,,
402,Acute hepatitis B,400,Acute hepatitis,4,A.5.8.2,68,,
403,Acute hepatitis C,400,Acute hepatitis,4,A.5.8.3,69,,
404,Acute hepatitis E,400,Acute hepatitis,4,A.5.8.4,70,,
408,Other unspecified infectious diseases,961,Other infectious diseases,3,A.5.9,71,,
962,Maternal and neonatal disorders,295,"Communicable, maternal, neonatal, and nutritional diseases",2,A.6,72,,
366,Maternal disorders,962,Maternal and neonatal disorders,3,A.6.1,73,,
367,Maternal hemorrhage,366,Maternal disorders,4,A.6.1.1,74,,
368,Maternal sepsis and other maternal infections,366,Maternal disorders,4,A.6.1.2,75,,
369,Maternal hypertensive disorders,366,Maternal disorders,4,A.6.1.3,76,,
370,Maternal obstructed labor and uterine rupture,366,Maternal disorders,4,A.6.1.4,77,,
995,Maternal abortion and miscarriage,366,Maternal disorders,4,A.6.1.5,78,,
374,Ectopic pregnancy,366,Maternal disorders,4,A.6.1.6,79,,
375,Indirect maternal deaths,366,Maternal disorders,4,A.6.1.7,80,X,
376,Late maternal deaths,366,Maternal disorders,4,A.6.1.8,81,X,
741,Maternal deaths aggravated by HIV/AIDS,366,Maternal disorders,4,A.6.1.9,82,X,
379,Other maternal disorders,366,Maternal disorders,4,A.6.1.10,83,,
380,Neonatal disorders,962,Maternal and neonatal disorders,3,A.6.2,84,,
381,Neonatal preterm birth,380,Neonatal disorders,4,A.6.2.1,85,,
382,Neonatal encephalopathy due to birth asphyxia and trauma,380,Neonatal disorders,4,A.6.2.2,86,,
383,Neonatal sepsis and other neonatal infections,380,Neonatal disorders,4,A.6.2.3,87,,
384,Hemolytic disease and other neonatal jaundice,380,Neonatal disorders,4,A.6.2.4,88,,
385,Other neonatal disorders,380,Neonatal disorders,4,A.6.2.5,89,,
386,Nutritional deficiencies,295,"Communicable, maternal, neonatal, and nutritional diseases",2,A.7,90,,
387,Protein-energy malnutrition,386,Nutritional deficiencies,3,A.7.1,91,,
388,Iodine deficiency,386,Nutritional deficiencies,3,A.7.2,92,,X
389,Vitamin A deficiency,386,Nutritional deficiencies,3,A.7.3,93,,X
390,Dietary iron deficiency,386,Nutritional deficiencies,3,A.7.4,94,,X
391,Other nutritional deficiencies,386,Nutritional deficiencies,3,A.7.5,95,,
409,Non-communicable diseases,294,All causes,1,B,96,,
410,Neoplasms,409,Non-communicable diseases,2,B.1,97,,
444,Lip and oral cavity cancer,410,Neoplasms,3,B.1.1,98,,
447,Nasopharynx cancer,410,Neoplasms,3,B.1.2,99,,
450,Other pharynx cancer,410,Neoplasms,3,B.1.3,100,,
411,Esophageal cancer,410,Neoplasms,3,B.1.4,101,,
414,Stomach cancer,410,Neoplasms,3,B.1.5,102,,
441,Colon and rectum cancer,410,Neoplasms,3,B.1.6,103,,
417,Liver cancer,410,Neoplasms,3,B.1.7,104,,
418,Liver cancer due to hepatitis B,417,Liver cancer,4,B.1.7.1,105,,
419,Liver cancer due to hepatitis C,417,Liver cancer,4,B.1.7.2,106,,
420,Liver cancer due to alcohol use,417,Liver cancer,4,B.1.7.3,107,,
996,Liver cancer due to NASH,417,Liver cancer,4,B.1.7.4,108,,
1021,Liver cancer due to other causes,417,Liver cancer,4,B.1.7.5,109,,
453,Gallbladder and biliary tract cancer,410,Neoplasms,3,B.1.8,110,,
456,Pancreatic cancer,410,Neoplasms,3,B.1.9,111,,
423,Larynx cancer,410,Neoplasms,3,B.1.10,112,,
426,"Tracheal, bronchus, and lung cancer",410,Neoplasms,3,B.1.11,113,,
459,Malignant skin melanoma,410,Neoplasms,3,B.1.12,114,,
462,Non-melanoma skin cancer,410,Neoplasms,3,B.1.13,115,,
849,Non-melanoma skin cancer (squamous-cell carcinoma),462,Non-melanoma skin cancer,4,B.1.13.1,116,,
850,Non-melanoma skin cancer (basal-cell carcinoma),462,Non-melanoma skin cancer,4,B.1.13.2,117,,X
429,Breast cancer,410,Neoplasms,3,B.1.14,118,,
432,Cervical cancer,410,Neoplasms,3,B.1.15,119,,
435,Uterine cancer,410,Neoplasms,3,B.1.16,120,,
465,Ovarian cancer,410,Neoplasms,3,B.1.17,121,,
438,Prostate cancer,410,Neoplasms,3,B.1.18,122,,
468,Testicular cancer,410,Neoplasms,3,B.1.19,123,,
471,Kidney cancer,410,Neoplasms,3,B.1.20,124,,
474,Bladder cancer,410,Neoplasms,3,B.1.21,125,,
477,Brain and central nervous system cancer,410,Neoplasms,3,B.1.22,126,,
480,Thyroid cancer,410,Neoplasms,3,B.1.23,127,,
483,Mesothelioma,410,Neoplasms,3,B.1.24,128,,
484,Hodgkin lymphoma,410,Neoplasms,3,B.1.25,129,,
485,Non-Hodgkin lymphoma,410,Neoplasms,3,B.1.26,130,,
486,Multiple myeloma,410,Neoplasms,3,B.1.27,131,,
487,Leukemia,410,Neoplasms,3,B.1.28,132,,
845,Acute lymphoid leukemia,487,Leukemia,4,B.1.28.1,133,,
846,Chronic lymphoid leukemia,487,Leukemia,4,B.1.28.2,134,,
847,Acute myeloid leukemia,487,Leukemia,4,B.1.28.3,135,,
848,Chronic myeloid leukemia,487,Leukemia,4,B.1.28.4,136,,
943,Other leukemia,487,Leukemia,4,B.1.28.5,137,,
1022,Other malignant neoplasms,410,Neoplasms,3,B.1.29,138,,
490,Other neoplasms,410,Neoplasms,3,B.1.30,139,,
964,"Myelodysplastic, myeloproliferative, and other hematopoietic neoplasms",490,Other neoplasms,4,B.1.30.1,140,,
965,Benign and in situ intestinal neoplasms,490,Other neoplasms,4,B.1.30.2,141,,X
966,Benign and in situ cervical and uterine neoplasms,490,Other neoplasms,4,B.1.30.3,142,,X
967,Other benign and in situ neoplasms,490,Other neoplasms,4,B.1.30.4,143,,X
491,Cardiovascular diseases,409,Non-communicable diseases,2,B.2,144,,
492,Rheumatic heart disease,491,Cardiovascular diseases,3,B.2.1,145,,
493,Ischemic heart disease,491,Cardiovascular diseases,3,B.2.2,146,,
494,Stroke,491,Cardiovascular diseases,3,B.2.3,147,,
495,Ischemic stroke,494,Stroke,4,B.2.3.1,148,,
496,Intracerebral hemorrhage,494,Stroke,4,B.2.3.2,149,,
497,Subarachnoid hemorrhage,494,Stroke,4,B.2.3.3,150,,
498,Hypertensive heart disease,491,Cardiovascular diseases,3,B.2.4,151,,
504,Non-rheumatic valvular heart disease,491,Cardiovascular diseases,3,B.2.5,152,,
968,Non-rheumatic calcific aortic valve disease,504,Non-rheumatic valvular heart disease,4,B.2.5.1,153,,
969,Non-rheumatic degenerative mitral valve disease,504,Non-rheumatic valvular heart disease,4,B.2.5.2,154,,
970,Other non-rheumatic valve diseases,504,Non-rheumatic valvular heart disease,4,B.2.5.3,155,,
499,Cardiomyopathy and myocarditis,491,Cardiovascular diseases,3,B.2.6,156,,
942,Myocarditis,499,Cardiomyopathy and myocarditis,4,B.2.6.1,157,,
938,Alcoholic cardiomyopathy,499,Cardiomyopathy and myocarditis,4,B.2.6.2,158,,
944,Other cardiomyopathy,499,Cardiomyopathy and myocarditis,4,B.2.6.3,159,,
500,Atrial fibrillation and flutter,491,Cardiovascular diseases,3,B.2.8,160,,
501,Aortic aneurysm,491,Cardiovascular diseases,3,B.2.9,161,X,
502,Peripheral artery disease,491,Cardiovascular diseases,3,B.2.10,162,,
503,Endocarditis,491,Cardiovascular diseases,3,B.2.11,163,,
1023,Other cardiovascular and circulatory diseases,491,Cardiovascular diseases,3,B.2.12,164,,
508,Chronic respiratory diseases,409,Non-communicable diseases,2,B.3,165,,
509,Chronic obstructive pulmonary disease,508,Chronic respiratory diseases,3,B.3.1,166,,
510,Pneumoconiosis,508,Chronic respiratory diseases,3,B.3.2,167,,
511,Silicosis,510,Pneumoconiosis,4,B.3.2.1,168,,
512,Asbestosis,510,Pneumoconiosis,4,B.3.2.2,169,,
513,Coal workers pneumoconiosis,510,Pneumoconiosis,4,B.3.2.3,170,,
514,Other pneumoconiosis,510,Pneumoconiosis,4,B.3.2.4,171,,
515,Asthma,508,Chronic respiratory diseases,3,B.3.3,172,,
516,Interstitial lung disease and pulmonary sarcoidosis,508,Chronic respiratory diseases,3,B.3.4,173,,
520,Other chronic respiratory diseases,508,Chronic respiratory diseases,3,B.3.5,174,,
526,Digestive diseases,409,Non-communicable diseases,2,B.4,175,,
521,Cirrhosis and other chronic liver diseases,526,Digestive diseases,3,B.4.1,176,,
522,Cirrhosis and other chronic liver diseases due to hepatitis B,521,Cirrhosis and other chronic liver diseases,4,B.4.1.1,177,,
523,Cirrhosis and other chronic liver diseases due to hepatitis C,521,Cirrhosis and other chronic liver diseases,4,B.4.1.2,178,,
524,Cirrhosis and other chronic liver diseases due to alcohol use,521,Cirrhosis and other chronic liver diseases,4,B.4.1.3,179,,
971,Cirrhosis and other chronic liver diseases due to NAFLD,521,Cirrhosis and other chronic liver diseases,4,B.4.1.4,180,,
525,Cirrhosis and other chronic liver diseases due to other causes,521,Cirrhosis and other chronic liver diseases,4,B.4.1.5,181,,
992,Upper digestive system diseases,526,Digestive diseases,3,B.4.2,182,,
527,Peptic ulcer disease,992,Upper digestive system diseases,4,B.4.2.1,183,,
528,Gastritis and duodenitis,992,Upper digestive system diseases,4,B.4.2.2,184,,
536,Gastroesophageal reflux disease,992,Upper digestive system diseases,4,B.4.2.3,185,,X
529,Appendicitis,526,Digestive diseases,3,B.4.3,186,,
530,Paralytic ileus and intestinal obstruction,526,Digestive diseases,3,B.4.4,187,,
531,"Inguinal, femoral, and abdominal hernia",526,Digestive diseases,3,B.4.5,188,,
532,Inflammatory bowel disease,526,Digestive diseases,3,B.4.6,189,,
533,Vascular intestinal disorders,526,Digestive diseases,3,B.4.7,190,,
534,Gallbladder and biliary diseases,526,Digestive diseases,3,B.4.8,191,,
535,Pancreatitis,526,Digestive diseases,3,B.4.9,192,,
541,Other digestive diseases,526,Digestive diseases,3,B.4.10,193,,
542,Neurological disorders,409,Non-communicable diseases,2,B.5,194,,
543,Alzheimer's disease and other dementias,542,Neurological disorders,3,B.5.1,195,,
544,Parkinson's disease,542,Neurological disorders,3,B.5.2,196,,
545,Idiopathic epilepsy,542,Neurological disorders,3,B.5.3,197,,
546,Multiple sclerosis,542,Neurological disorders,3,B.5.4,198,,
554,Motor neuron disease,542,Neurological disorders,3,B.5.5,199,,
972,Headache disorders,542,Neurological disorders,3,B.5.6,200,,X
547,Migraine,972,Headache disorders,4,B.5.6.1,201,,X
548,Tension-type headache,972,Headache disorders,4,B.5.6.2,202,,X
557,Other neurological disorders,542,Neurological disorders,3,B.5.7,203,,
558,Mental disorders,409,Non-communicable diseases,2,B.6,204,,
559,Schizophrenia,558,Mental disorders,3,B.6.1,205,,X
567,Depressive disorders,558,Mental disorders,3,B.6.2,206,,X
568,Major depressive disorder,567,Depressive disorders,4,B.6.2.1,207,,X
569,Dysthymia,567,Depressive disorders,4,B.6.2.2,208,,X
570,Bipolar disorder,558,Mental disorders,3,B.6.3,209,,X
571,Anxiety disorders,558,Mental disorders,3,B.6.4,210,,X
572,Eating disorders,558,Mental disorders,3,B.6.5,211,,
573,Anorexia nervosa,572,Eating disorders,4,B.6.5.1,212,,
574,Bulimia nervosa,572,Eating disorders,4,B.6.5.2,213,,
575,Autism spectrum disorders,558,Mental disorders,3,B.6.6,214,,X
578,Attention-deficit/hyperactivity disorder,558,Mental disorders,3,B.6.7,215,,X
579,Conduct disorder,558,Mental disorders,3,B.6.8,216,,X
582,Idiopathic developmental intellectual disability,558,Mental disorders,3,B.6.9,217,,X
585,Other mental disorders,558,Mental disorders,3,B.6.10,218,,X
973,Substance use disorders,409,Non-communicable diseases,2,B.7,219,,
560,Alcohol use disorders,973,Substance use disorders,3,B.7.1,220,,
561,Drug use disorders,973,Substance use disorders,3,B.7.2,221,,
562,Opioid use disorders,561,Drug use disorders,4,B.7.2.1,222,,
563,Cocaine use disorders,561,Drug use disorders,4,B.7.2.2,223,,
564,Amphetamine use disorders,561,Drug use disorders,4,B.7.2.3,224,,
565,Cannabis use disorders,561,Drug use disorders,4,B.7.2.4,225,,X
566,Other drug use disorders,561,Drug use disorders,4,B.7.2.5,226,,
974,Diabetes and kidney diseases,409,Non-communicable diseases,2,B.8,227,,
587,Diabetes mellitus,974,Diabetes and kidney diseases,3,B.8.1,228,,
975,Diabetes mellitus type 1,587,Diabetes mellitus,4,B.8.1.1,229,,
976,Diabetes mellitus type 2,587,Diabetes mellitus,4,B.8.1.2,230,,
589,Chronic kidney disease,974,Diabetes and kidney diseases,3,B.8.2,231,,
997,Chronic kidney disease due to diabetes mellitus type 1,589,Chronic kidney disease,4,B.8.2.1,232,,
998,Chronic kidney disease due to diabetes mellitus type 2,589,Chronic kidney disease,4,B.8.2.2,233,,
591,Chronic kidney disease due to hypertension,589,Chronic kidney disease,4,B.8.2.3,234,,
592,Chronic kidney disease due to glomerulonephritis,589,Chronic kidney disease,4,B.8.2.4,235,,
593,Chronic kidney disease due to other and unspecified causes,589,Chronic kidney disease,4,B.8.2.5,236,,
588,Acute glomerulonephritis,974,Diabetes and kidney diseases,3,B.8.3,237,,
653,Skin and subcutaneous diseases,409,Non-communicable diseases,2,B.9,238,,
654,Dermatitis,653,Skin and subcutaneous diseases,3,B.9.1,239,,X
977,Atopic dermatitis,654,Dermatitis,4,B.9.1.1,240,,X
978,Contact dermatitis,654,Dermatitis,4,B.9.1.2,241,,X
979,Seborrhoeic dermatitis,654,Dermatitis,4,B.9.1.3,242,,X
655,Psoriasis,653,Skin and subcutaneous diseases,3,B.9.2,243,,X
980,Bacterial skin diseases,653,Skin and subcutaneous diseases,3,B.9.3,244,,
656,Cellulitis,980,Bacterial skin diseases,4,B.9.3.1,245,,
657,Pyoderma,980,Bacterial skin diseases,4,B.9.3.2,246,,
658,Scabies,653,Skin and subcutaneous diseases,3,B.9.4,247,,X
659,Fungal skin diseases,653,Skin and subcutaneous diseases,3,B.9.5,248,,X
660,Viral skin diseases,653,Skin and subcutaneous diseases,3,B.9.6,249,,X
661,Acne vulgaris,653,Skin and subcutaneous diseases,3,B.9.7,250,,X
662,Alopecia areata,653,Skin and subcutaneous diseases,3,B.9.8,251,,X
663,Pruritus,653,Skin and subcutaneous diseases,3,B.9.9,252,,X
664,Urticaria,653,Skin and subcutaneous diseases,3,B.9.10,253,,X
665,Decubitus ulcer,653,Skin and subcutaneous diseases,3,B.9.11,254,,
668,Other skin and subcutaneous diseases,653,Skin and subcutaneous diseases,3,B.9.12,255,,
669,Sense organ diseases,409,Non-communicable diseases,2,B.10,256,,X
981,Blindness and vision loss,669,Sense organ diseases,3,B.10.1,257,,X
670,Glaucoma,981,Blindness and vision loss,4,B.10.1.1,258,,X
671,Cataract,981,Blindness and vision loss,4,B.10.1.2,259,,X
672,Age-related macular degeneration,981,Blindness and vision loss,4,B.10.1.3,260,,X
999,Refraction disorders,981,Blindness and vision loss,4,B.10.1.4,261,,X
1000,Near vision loss,981,Blindness and vision loss,4,B.10.1.5,262,,X
675,Other vision loss,981,Blindness and vision loss,4,B.10.1.6,263,,X
674,Age-related and other hearing loss,669,Sense organ diseases,3,B.10.2,264,,X
679,Other sense organ diseases,669,Sense organ diseases,3,B.10.3,265,,X
626,Musculoskeletal disorders,409,Non-communicable diseases,2,B.11,266,,
627,Rheumatoid arthritis,626,Musculoskeletal disorders,3,B.11.1,267,,
628,Osteoarthritis,626,Musculoskeletal disorders,3,B.11.2,268,,X
1014,Osteoarthritis hip,628,Osteoarthritis,4,B.11.2.1,269,,X
1015,Osteoarthritis knee,628,Osteoarthritis,4,B.11.2.2,270,,X
1016,Osteoarthritis hand,628,Osteoarthritis,4,B.11.2.3,271,,X
1017,Osteoarthritis other,628,Osteoarthritis,4,B.11.2.4,272,,X
630,Low back pain,626,Musculoskeletal disorders,3,B.11.3,273,,X
631,Neck pain,626,Musculoskeletal disorders,3,B.11.4,274,,X
632,Gout,626,Musculoskeletal disorders,3,B.11.5,275,,X
639,Other musculoskeletal disorders,626,Musculoskeletal disorders,3,B.11.6,276,,
640,Other non-communicable diseases,409,Non-communicable diseases,2,B.12,277,,
641,Congenital birth defects,640,Other non-communicable diseases,3,B.12.1,278,,
642,Neural tube defects,641,Congenital birth defects,4,B.12.1.1,279,,
643,Congenital heart anomalies,641,Congenital birth defects,4,B.12.1.2,280,,
644,Orofacial clefts,641,Congenital birth defects,4,B.12.1.3,281,,
645,Down syndrome,641,Congenital birth defects,4,B.12.1.4,282,,
646,Turner syndrome,641,Congenital birth defects,4,B.12.1.5,283,,X
647,Klinefelter syndrome,641,Congenital birth defects,4,B.12.1.6,284,,X
648,Other chromosomal abnormalities,641,Congenital birth defects,4,B.12.1.7,285,,
649,Congenital musculoskeletal and limb anomalies,641,Congenital birth defects,4,B.12.1.8,286,,
650,Urogenital congenital anomalies,641,Congenital birth defects,4,B.12.1.9,287,,
651,Digestive congenital anomalies,641,Congenital birth defects,4,B.12.1.10,288,,
652,Other congenital birth defects,641,Congenital birth defects,4,B.12.1.11,289,,
594,Urinary diseases and male infertility,640,Other non-communicable diseases,3,B.12.2,290,,
595,Urinary tract infections and interstitial nephritis,594,Urinary diseases and male infertility,4,B.12.2.1,291,,
596,Urolithiasis,594,Urinary diseases and male infertility,4,B.12.2.2,292,,
597,Benign prostatic hyperplasia,594,Urinary diseases and male infertility,4,B.12.2.3,293,,X
598,Male infertility,594,Urinary diseases and male infertility,4,B.12.2.4,294,,X
602,Other urinary diseases,594,Urinary diseases and male infertility,4,B.12.2.5,295,,
603,Gynecological diseases,640,Other non-communicable diseases,3,B.12.3,296,,
604,Uterine fibroids,603,Gynecological diseases,4,B.12.3.1,297,,
605,Polycystic ovarian syndrome,603,Gynecological diseases,4,B.12.3.2,298,,X
606,Female infertility,603,Gynecological diseases,4,B.12.3.3,299,,X
607,Endometriosis,603,Gynecological diseases,4,B.12.3.4,300,,
608,Genital prolapse,603,Gynecological diseases,4,B.12.3.5,301,,
609,Premenstrual syndrome,603,Gynecological diseases,4,B.12.3.6,302,,X
612,Other gynecological diseases,603,Gynecological diseases,4,B.12.3.7,303,,
613,Hemoglobinopathies and hemolytic anemias,640,Other non-communicable diseases,3,B.12.4,304,,
614,Thalassemias,613,Hemoglobinopathies and hemolytic anemias,4,B.12.4.1,305,,
837,Thalassemias trait,613,Hemoglobinopathies and hemolytic anemias,4,B.12.4.2,306,,X
615,Sickle cell disorders,613,Hemoglobinopathies and hemolytic anemias,4,B.12.4.3,307,,
838,Sickle cell trait,613,Hemoglobinopathies and hemolytic anemias,4,B.12.4.4,308,,X
616,G6PD deficiency,613,Hemoglobinopathies and hemolytic anemias,4,B.12.4.5,309,,
839,G6PD trait,613,Hemoglobinopathies and hemolytic anemias,4,B.12.4.6,310,,X
618,Other hemoglobinopathies and hemolytic anemias,613,Hemoglobinopathies and hemolytic anemias,4,B.12.4.7,311,,
619,"Endocrine, metabolic, blood, and immune disorders",640,Other non-communicable diseases,3,B.12.5,312,,
680,Oral disorders,640,Other non-communicable diseases,3,B.12.6,313,,X
681,Caries of deciduous teeth,680,Oral disorders,4,B.12.6.1,314,,X
682,Caries of permanent teeth,680,Oral disorders,4,B.12.6.2,315,,X
683,Periodontal diseases,680,Oral disorders,4,B.12.6.3,316,,X
684,Edentulism,680,Oral disorders,4,B.12.6.4,317,,X
685,Other oral disorders,680,Oral disorders,4,B.12.6.5,318,,X
686,Sudden infant death syndrome,640,Other non-communicable diseases,3,B.12.7,319,X,
687,Injuries,294,All causes,1,C,320,,
688,Transport injuries,687,Injuries,2,C.1,321,,
689,Road injuries,688,Transport injuries,3,C.1.1,322,,
690,Pedestrian road injuries,689,Road injuries,4,C.1.1.1,323,,
691,Cyclist road injuries,689,Road injuries,4,C.1.1.2,324,,
692,Motorcyclist road injuries,689,Road injuries,4,C.1.1.3,325,,
693,Motor vehicle road injuries,689,Road injuries,4,C.1.1.4,326,,
694,Other road injuries,689,Road injuries,4,C.1.1.5,327,,
695,Other transport injuries,688,Transport injuries,3,C.1.2,328,,
696,Unintentional injuries,687,Injuries,2,C.2,329,,
697,Falls,696,Unintentional injuries,3,C.2.1,330,,
698,Drowning,696,Unintentional injuries,3,C.2.2,331,,
699,"Fire, heat, and hot substances",696,Unintentional injuries,3,C.2.3,332,,
700,Poisonings,696,Unintentional injuries,3,C.2.4,333,,
701,Poisoning by carbon monoxide,700,Poisonings,4,C.2.4.1,334,,
703,Poisoning by other means,700,Poisonings,4,C.2.4.2,335,,
704,Exposure to mechanical forces,696,Unintentional injuries,3,C.2.5,336,,
705,Unintentional firearm injuries,704,Exposure to mechanical forces,4,C.2.5.1,337,,
707,Other exposure to mechanical forces,704,Exposure to mechanical forces,4,C.2.5.2,338,,
708,Adverse effects of medical treatment,696,Unintentional injuries,3,C.2.6,339,,
709,Animal contact,696,Unintentional injuries,3,C.2.7,340,,
710,Venomous animal contact,709,Animal contact,4,C.2.7.1,341,,
711,Non-venomous animal contact,709,Animal contact,4,C.2.7.2,342,,
712,Foreign body,696,Unintentional injuries,3,C.2.8,343,,
713,Pulmonary aspiration and foreign body in airway,712,Foreign body,4,C.2.8.1,344,,
714,Foreign body in eyes,712,Foreign body,4,C.2.8.2,345,,X
715,Foreign body in other body part,712,Foreign body,4,C.2.8.3,346,,
842,Environmental heat and cold exposure,696,Unintentional injuries,3,C.2.9,347,,
729,Exposure to forces of nature,696,Unintentional injuries,3,C.2.10,348,,
716,Other unintentional injuries,696,Unintentional injuries,3,C.2.11,349,,
717,Self-harm and interpersonal violence,687,Injuries,2,C.3,350,,
718,Self-harm,717,Self-harm and interpersonal violence,3,C.3.1,351,,
721,Self-harm by firearm,718,Self-harm,4,C.3.1.1,352,,
723,Self-harm by other specified means,718,Self-harm,4,C.3.1.2,353,,
724,Interpersonal violence,717,Self-harm and interpersonal violence,3,C.3.2,354,,
725,Physical violence by firearm,724,Interpersonal violence,4,C.3.2.1,355,,
726,Physical violence by sharp object,724,Interpersonal violence,4,C.3.2.2,356,,
941,Sexual violence,724,Interpersonal violence,4,C.3.2.3,357,,X
727,Physical violence by other means,724,Interpersonal violence,4,C.3.2.4,358,,
945,Conflict and terrorism,717,Self-harm and interpersonal violence,3,C.3.3,359,,
854,Executions and police conflict,717,Self-harm and interpersonal violence,3,C.3.4,360,,
1029,Total cancers,294,All causes,1,D,361,,
1026,Total burden related to hepatitis B,294,All causes,1,E,362,,
1027,Total burden related to hepatitis C,294,All causes,1,F,363,,
1028,Total burden related to Non-alcoholic fatty liver disease (NAFLD),294,All causes,1,G,364,,
1 Cause ID Cause Name Parent ID Parent Name Level Cause Outline Sort Order YLL Only YLD Only
2 294 All causes 294 All causes 0 Total 1
3 295 Communicable, maternal, neonatal, and nutritional diseases 294 All causes 1 A 2
4 955 HIV/AIDS and sexually transmitted infections 295 Communicable, maternal, neonatal, and nutritional diseases 2 A.1 3
5 298 HIV/AIDS 955 HIV/AIDS and sexually transmitted infections 3 A.1.1 4
6 948 HIV/AIDS - Drug-susceptible Tuberculosis 298 HIV/AIDS 4 A.1.1.1 5
7 949 HIV/AIDS - Multidrug-resistant Tuberculosis without extensive drug resistance 298 HIV/AIDS 4 A.1.1.2 6
8 950 HIV/AIDS - Extensively drug-resistant Tuberculosis 298 HIV/AIDS 4 A.1.1.3 7
9 300 HIV/AIDS resulting in other diseases 298 HIV/AIDS 4 A.1.1.4 8
10 393 Sexually transmitted infections excluding HIV 955 HIV/AIDS and sexually transmitted infections 3 A.1.2 9
11 394 Syphilis 393 Sexually transmitted infections excluding HIV 4 A.1.2.1 10
12 395 Chlamydial infection 393 Sexually transmitted infections excluding HIV 4 A.1.2.2 11
13 396 Gonococcal infection 393 Sexually transmitted infections excluding HIV 4 A.1.2.3 12
14 397 Trichomoniasis 393 Sexually transmitted infections excluding HIV 4 A.1.2.4 13 X
15 398 Genital herpes 393 Sexually transmitted infections excluding HIV 4 A.1.2.5 14 X
16 399 Other sexually transmitted infections 393 Sexually transmitted infections excluding HIV 4 A.1.2.6 15
17 956 Respiratory infections and tuberculosis 295 Communicable, maternal, neonatal, and nutritional diseases 2 A.2 16
18 297 Tuberculosis 956 Respiratory infections and tuberculosis 3 A.2.1 17
19 954 Latent tuberculosis infection 297 Tuberculosis 4 A.2.1.1 18 X
20 934 Drug-susceptible tuberculosis 297 Tuberculosis 4 A.2.1.2 19
21 946 Multidrug-resistant tuberculosis without extensive drug resistance 297 Tuberculosis 4 A.2.1.3 20
22 947 Extensively drug-resistant tuberculosis 297 Tuberculosis 4 A.2.1.4 21
23 322 Lower respiratory infections 956 Respiratory infections and tuberculosis 3 A.2.2 22
24 328 Upper respiratory infections 956 Respiratory infections and tuberculosis 3 A.2.3 23
25 329 Otitis media 956 Respiratory infections and tuberculosis 3 A.2.4 24
26 957 Enteric infections 295 Communicable, maternal, neonatal, and nutritional diseases 2 A.3 25
27 302 Diarrheal diseases 957 Enteric infections 3 A.3.1 26
28 958 Typhoid and paratyphoid 957 Enteric infections 3 A.3.2 27
29 319 Typhoid fever 958 Typhoid and paratyphoid 4 A.3.2.1 28
30 320 Paratyphoid fever 958 Typhoid and paratyphoid 4 A.3.2.2 29
31 959 Invasive Non-typhoidal Salmonella (iNTS) 957 Enteric infections 3 A.3.3 30
32 321 Other intestinal infectious diseases 957 Enteric infections 3 A.3.4 31
33 344 Neglected tropical diseases and malaria 295 Communicable, maternal, neonatal, and nutritional diseases 2 A.4 32
34 345 Malaria 344 Neglected tropical diseases and malaria 3 A.4.1 33
35 346 Chagas disease 344 Neglected tropical diseases and malaria 3 A.4.2 34
36 347 Leishmaniasis 344 Neglected tropical diseases and malaria 3 A.4.3 35
37 348 Visceral leishmaniasis 347 Leishmaniasis 4 A.4.3.1 36
38 349 Cutaneous and mucocutaneous leishmaniasis 347 Leishmaniasis 4 A.4.3.2 37 X
39 350 African trypanosomiasis 344 Neglected tropical diseases and malaria 3 A.4.4 38
40 351 Schistosomiasis 344 Neglected tropical diseases and malaria 3 A.4.5 39
41 352 Cysticercosis 344 Neglected tropical diseases and malaria 3 A.4.6 40
42 353 Cystic echinococcosis 344 Neglected tropical diseases and malaria 3 A.4.7 41
43 354 Lymphatic filariasis 344 Neglected tropical diseases and malaria 3 A.4.8 42 X
44 355 Onchocerciasis 344 Neglected tropical diseases and malaria 3 A.4.9 43 X
45 356 Trachoma 344 Neglected tropical diseases and malaria 3 A.4.10 44 X
46 357 Dengue 344 Neglected tropical diseases and malaria 3 A.4.11 45
47 358 Yellow fever 344 Neglected tropical diseases and malaria 3 A.4.12 46
48 359 Rabies 344 Neglected tropical diseases and malaria 3 A.4.13 47
49 360 Intestinal nematode infections 344 Neglected tropical diseases and malaria 3 A.4.14 48
50 361 Ascariasis 360 Intestinal nematode infections 4 A.4.14.1 49
51 362 Trichuriasis 360 Intestinal nematode infections 4 A.4.14.2 50 X
52 363 Hookworm disease 360 Intestinal nematode infections 4 A.4.14.3 51 X
53 364 Food-borne trematodiases 344 Neglected tropical diseases and malaria 3 A.4.15 52 X
54 405 Leprosy 344 Neglected tropical diseases and malaria 3 A.4.16 53 X
55 843 Ebola 344 Neglected tropical diseases and malaria 3 A.4.17 54
56 935 Zika virus 344 Neglected tropical diseases and malaria 3 A.4.18 55
57 936 Guinea worm disease 344 Neglected tropical diseases and malaria 3 A.4.19 56 X
58 365 Other neglected tropical diseases 344 Neglected tropical diseases and malaria 3 A.4.20 57
59 961 Other infectious diseases 295 Communicable, maternal, neonatal, and nutritional diseases 2 A.5 58
60 332 Meningitis 961 Other infectious diseases 3 A.5.1 59
61 337 Encephalitis 961 Other infectious diseases 3 A.5.2 60
62 338 Diphtheria 961 Other infectious diseases 3 A.5.3 61
63 339 Whooping cough 961 Other infectious diseases 3 A.5.4 62
64 340 Tetanus 961 Other infectious diseases 3 A.5.5 63
65 341 Measles 961 Other infectious diseases 3 A.5.6 64
66 342 Varicella and herpes zoster 961 Other infectious diseases 3 A.5.7 65
67 400 Acute hepatitis 961 Other infectious diseases 3 A.5.8 66
68 401 Acute hepatitis A 400 Acute hepatitis 4 A.5.8.1 67
69 402 Acute hepatitis B 400 Acute hepatitis 4 A.5.8.2 68
70 403 Acute hepatitis C 400 Acute hepatitis 4 A.5.8.3 69
71 404 Acute hepatitis E 400 Acute hepatitis 4 A.5.8.4 70
72 408 Other unspecified infectious diseases 961 Other infectious diseases 3 A.5.9 71
73 962 Maternal and neonatal disorders 295 Communicable, maternal, neonatal, and nutritional diseases 2 A.6 72
74 366 Maternal disorders 962 Maternal and neonatal disorders 3 A.6.1 73
75 367 Maternal hemorrhage 366 Maternal disorders 4 A.6.1.1 74
76 368 Maternal sepsis and other maternal infections 366 Maternal disorders 4 A.6.1.2 75
77 369 Maternal hypertensive disorders 366 Maternal disorders 4 A.6.1.3 76
78 370 Maternal obstructed labor and uterine rupture 366 Maternal disorders 4 A.6.1.4 77
79 995 Maternal abortion and miscarriage 366 Maternal disorders 4 A.6.1.5 78
80 374 Ectopic pregnancy 366 Maternal disorders 4 A.6.1.6 79
81 375 Indirect maternal deaths 366 Maternal disorders 4 A.6.1.7 80 X
82 376 Late maternal deaths 366 Maternal disorders 4 A.6.1.8 81 X
83 741 Maternal deaths aggravated by HIV/AIDS 366 Maternal disorders 4 A.6.1.9 82 X
84 379 Other maternal disorders 366 Maternal disorders 4 A.6.1.10 83
85 380 Neonatal disorders 962 Maternal and neonatal disorders 3 A.6.2 84
86 381 Neonatal preterm birth 380 Neonatal disorders 4 A.6.2.1 85
87 382 Neonatal encephalopathy due to birth asphyxia and trauma 380 Neonatal disorders 4 A.6.2.2 86
88 383 Neonatal sepsis and other neonatal infections 380 Neonatal disorders 4 A.6.2.3 87
89 384 Hemolytic disease and other neonatal jaundice 380 Neonatal disorders 4 A.6.2.4 88
90 385 Other neonatal disorders 380 Neonatal disorders 4 A.6.2.5 89
91 386 Nutritional deficiencies 295 Communicable, maternal, neonatal, and nutritional diseases 2 A.7 90
92 387 Protein-energy malnutrition 386 Nutritional deficiencies 3 A.7.1 91
93 388 Iodine deficiency 386 Nutritional deficiencies 3 A.7.2 92 X
94 389 Vitamin A deficiency 386 Nutritional deficiencies 3 A.7.3 93 X
95 390 Dietary iron deficiency 386 Nutritional deficiencies 3 A.7.4 94 X
96 391 Other nutritional deficiencies 386 Nutritional deficiencies 3 A.7.5 95
97 409 Non-communicable diseases 294 All causes 1 B 96
98 410 Neoplasms 409 Non-communicable diseases 2 B.1 97
99 444 Lip and oral cavity cancer 410 Neoplasms 3 B.1.1 98
100 447 Nasopharynx cancer 410 Neoplasms 3 B.1.2 99
101 450 Other pharynx cancer 410 Neoplasms 3 B.1.3 100
102 411 Esophageal cancer 410 Neoplasms 3 B.1.4 101
103 414 Stomach cancer 410 Neoplasms 3 B.1.5 102
104 441 Colon and rectum cancer 410 Neoplasms 3 B.1.6 103
105 417 Liver cancer 410 Neoplasms 3 B.1.7 104
106 418 Liver cancer due to hepatitis B 417 Liver cancer 4 B.1.7.1 105
107 419 Liver cancer due to hepatitis C 417 Liver cancer 4 B.1.7.2 106
108 420 Liver cancer due to alcohol use 417 Liver cancer 4 B.1.7.3 107
109 996 Liver cancer due to NASH 417 Liver cancer 4 B.1.7.4 108
110 1021 Liver cancer due to other causes 417 Liver cancer 4 B.1.7.5 109
111 453 Gallbladder and biliary tract cancer 410 Neoplasms 3 B.1.8 110
112 456 Pancreatic cancer 410 Neoplasms 3 B.1.9 111
113 423 Larynx cancer 410 Neoplasms 3 B.1.10 112
114 426 Tracheal, bronchus, and lung cancer 410 Neoplasms 3 B.1.11 113
115 459 Malignant skin melanoma 410 Neoplasms 3 B.1.12 114
116 462 Non-melanoma skin cancer 410 Neoplasms 3 B.1.13 115
117 849 Non-melanoma skin cancer (squamous-cell carcinoma) 462 Non-melanoma skin cancer 4 B.1.13.1 116
118 850 Non-melanoma skin cancer (basal-cell carcinoma) 462 Non-melanoma skin cancer 4 B.1.13.2 117 X
119 429 Breast cancer 410 Neoplasms 3 B.1.14 118
120 432 Cervical cancer 410 Neoplasms 3 B.1.15 119
121 435 Uterine cancer 410 Neoplasms 3 B.1.16 120
122 465 Ovarian cancer 410 Neoplasms 3 B.1.17 121
123 438 Prostate cancer 410 Neoplasms 3 B.1.18 122
124 468 Testicular cancer 410 Neoplasms 3 B.1.19 123
125 471 Kidney cancer 410 Neoplasms 3 B.1.20 124
126 474 Bladder cancer 410 Neoplasms 3 B.1.21 125
127 477 Brain and central nervous system cancer 410 Neoplasms 3 B.1.22 126
128 480 Thyroid cancer 410 Neoplasms 3 B.1.23 127
129 483 Mesothelioma 410 Neoplasms 3 B.1.24 128
130 484 Hodgkin lymphoma 410 Neoplasms 3 B.1.25 129
131 485 Non-Hodgkin lymphoma 410 Neoplasms 3 B.1.26 130
132 486 Multiple myeloma 410 Neoplasms 3 B.1.27 131
133 487 Leukemia 410 Neoplasms 3 B.1.28 132
134 845 Acute lymphoid leukemia 487 Leukemia 4 B.1.28.1 133
135 846 Chronic lymphoid leukemia 487 Leukemia 4 B.1.28.2 134
136 847 Acute myeloid leukemia 487 Leukemia 4 B.1.28.3 135
137 848 Chronic myeloid leukemia 487 Leukemia 4 B.1.28.4 136
138 943 Other leukemia 487 Leukemia 4 B.1.28.5 137
139 1022 Other malignant neoplasms 410 Neoplasms 3 B.1.29 138
140 490 Other neoplasms 410 Neoplasms 3 B.1.30 139
141 964 Myelodysplastic, myeloproliferative, and other hematopoietic neoplasms 490 Other neoplasms 4 B.1.30.1 140
142 965 Benign and in situ intestinal neoplasms 490 Other neoplasms 4 B.1.30.2 141 X
143 966 Benign and in situ cervical and uterine neoplasms 490 Other neoplasms 4 B.1.30.3 142 X
144 967 Other benign and in situ neoplasms 490 Other neoplasms 4 B.1.30.4 143 X
145 491 Cardiovascular diseases 409 Non-communicable diseases 2 B.2 144
146 492 Rheumatic heart disease 491 Cardiovascular diseases 3 B.2.1 145
147 493 Ischemic heart disease 491 Cardiovascular diseases 3 B.2.2 146
148 494 Stroke 491 Cardiovascular diseases 3 B.2.3 147
149 495 Ischemic stroke 494 Stroke 4 B.2.3.1 148
150 496 Intracerebral hemorrhage 494 Stroke 4 B.2.3.2 149
151 497 Subarachnoid hemorrhage 494 Stroke 4 B.2.3.3 150
152 498 Hypertensive heart disease 491 Cardiovascular diseases 3 B.2.4 151
153 504 Non-rheumatic valvular heart disease 491 Cardiovascular diseases 3 B.2.5 152
154 968 Non-rheumatic calcific aortic valve disease 504 Non-rheumatic valvular heart disease 4 B.2.5.1 153
155 969 Non-rheumatic degenerative mitral valve disease 504 Non-rheumatic valvular heart disease 4 B.2.5.2 154
156 970 Other non-rheumatic valve diseases 504 Non-rheumatic valvular heart disease 4 B.2.5.3 155
157 499 Cardiomyopathy and myocarditis 491 Cardiovascular diseases 3 B.2.6 156
158 942 Myocarditis 499 Cardiomyopathy and myocarditis 4 B.2.6.1 157
159 938 Alcoholic cardiomyopathy 499 Cardiomyopathy and myocarditis 4 B.2.6.2 158
160 944 Other cardiomyopathy 499 Cardiomyopathy and myocarditis 4 B.2.6.3 159
161 500 Atrial fibrillation and flutter 491 Cardiovascular diseases 3 B.2.8 160
162 501 Aortic aneurysm 491 Cardiovascular diseases 3 B.2.9 161 X
163 502 Peripheral artery disease 491 Cardiovascular diseases 3 B.2.10 162
164 503 Endocarditis 491 Cardiovascular diseases 3 B.2.11 163
165 1023 Other cardiovascular and circulatory diseases 491 Cardiovascular diseases 3 B.2.12 164
166 508 Chronic respiratory diseases 409 Non-communicable diseases 2 B.3 165
167 509 Chronic obstructive pulmonary disease 508 Chronic respiratory diseases 3 B.3.1 166
168 510 Pneumoconiosis 508 Chronic respiratory diseases 3 B.3.2 167
169 511 Silicosis 510 Pneumoconiosis 4 B.3.2.1 168
170 512 Asbestosis 510 Pneumoconiosis 4 B.3.2.2 169
171 513 Coal workers pneumoconiosis 510 Pneumoconiosis 4 B.3.2.3 170
172 514 Other pneumoconiosis 510 Pneumoconiosis 4 B.3.2.4 171
173 515 Asthma 508 Chronic respiratory diseases 3 B.3.3 172
174 516 Interstitial lung disease and pulmonary sarcoidosis 508 Chronic respiratory diseases 3 B.3.4 173
175 520 Other chronic respiratory diseases 508 Chronic respiratory diseases 3 B.3.5 174
176 526 Digestive diseases 409 Non-communicable diseases 2 B.4 175
177 521 Cirrhosis and other chronic liver diseases 526 Digestive diseases 3 B.4.1 176
178 522 Cirrhosis and other chronic liver diseases due to hepatitis B 521 Cirrhosis and other chronic liver diseases 4 B.4.1.1 177
179 523 Cirrhosis and other chronic liver diseases due to hepatitis C 521 Cirrhosis and other chronic liver diseases 4 B.4.1.2 178
180 524 Cirrhosis and other chronic liver diseases due to alcohol use 521 Cirrhosis and other chronic liver diseases 4 B.4.1.3 179
181 971 Cirrhosis and other chronic liver diseases due to NAFLD 521 Cirrhosis and other chronic liver diseases 4 B.4.1.4 180
182 525 Cirrhosis and other chronic liver diseases due to other causes 521 Cirrhosis and other chronic liver diseases 4 B.4.1.5 181
183 992 Upper digestive system diseases 526 Digestive diseases 3 B.4.2 182
184 527 Peptic ulcer disease 992 Upper digestive system diseases 4 B.4.2.1 183
185 528 Gastritis and duodenitis 992 Upper digestive system diseases 4 B.4.2.2 184
186 536 Gastroesophageal reflux disease 992 Upper digestive system diseases 4 B.4.2.3 185 X
187 529 Appendicitis 526 Digestive diseases 3 B.4.3 186
188 530 Paralytic ileus and intestinal obstruction 526 Digestive diseases 3 B.4.4 187
189 531 Inguinal, femoral, and abdominal hernia 526 Digestive diseases 3 B.4.5 188
190 532 Inflammatory bowel disease 526 Digestive diseases 3 B.4.6 189
191 533 Vascular intestinal disorders 526 Digestive diseases 3 B.4.7 190
192 534 Gallbladder and biliary diseases 526 Digestive diseases 3 B.4.8 191
193 535 Pancreatitis 526 Digestive diseases 3 B.4.9 192
194 541 Other digestive diseases 526 Digestive diseases 3 B.4.10 193
195 542 Neurological disorders 409 Non-communicable diseases 2 B.5 194
196 543 Alzheimer's disease and other dementias 542 Neurological disorders 3 B.5.1 195
197 544 Parkinson's disease 542 Neurological disorders 3 B.5.2 196
198 545 Idiopathic epilepsy 542 Neurological disorders 3 B.5.3 197
199 546 Multiple sclerosis 542 Neurological disorders 3 B.5.4 198
200 554 Motor neuron disease 542 Neurological disorders 3 B.5.5 199
201 972 Headache disorders 542 Neurological disorders 3 B.5.6 200 X
202 547 Migraine 972 Headache disorders 4 B.5.6.1 201 X
203 548 Tension-type headache 972 Headache disorders 4 B.5.6.2 202 X
204 557 Other neurological disorders 542 Neurological disorders 3 B.5.7 203
205 558 Mental disorders 409 Non-communicable diseases 2 B.6 204
206 559 Schizophrenia 558 Mental disorders 3 B.6.1 205 X
207 567 Depressive disorders 558 Mental disorders 3 B.6.2 206 X
208 568 Major depressive disorder 567 Depressive disorders 4 B.6.2.1 207 X
209 569 Dysthymia 567 Depressive disorders 4 B.6.2.2 208 X
210 570 Bipolar disorder 558 Mental disorders 3 B.6.3 209 X
211 571 Anxiety disorders 558 Mental disorders 3 B.6.4 210 X
212 572 Eating disorders 558 Mental disorders 3 B.6.5 211
213 573 Anorexia nervosa 572 Eating disorders 4 B.6.5.1 212
214 574 Bulimia nervosa 572 Eating disorders 4 B.6.5.2 213
215 575 Autism spectrum disorders 558 Mental disorders 3 B.6.6 214 X
216 578 Attention-deficit/hyperactivity disorder 558 Mental disorders 3 B.6.7 215 X
217 579 Conduct disorder 558 Mental disorders 3 B.6.8 216 X
218 582 Idiopathic developmental intellectual disability 558 Mental disorders 3 B.6.9 217 X
219 585 Other mental disorders 558 Mental disorders 3 B.6.10 218 X
220 973 Substance use disorders 409 Non-communicable diseases 2 B.7 219
221 560 Alcohol use disorders 973 Substance use disorders 3 B.7.1 220
222 561 Drug use disorders 973 Substance use disorders 3 B.7.2 221
223 562 Opioid use disorders 561 Drug use disorders 4 B.7.2.1 222
224 563 Cocaine use disorders 561 Drug use disorders 4 B.7.2.2 223
225 564 Amphetamine use disorders 561 Drug use disorders 4 B.7.2.3 224
226 565 Cannabis use disorders 561 Drug use disorders 4 B.7.2.4 225 X
227 566 Other drug use disorders 561 Drug use disorders 4 B.7.2.5 226
228 974 Diabetes and kidney diseases 409 Non-communicable diseases 2 B.8 227
229 587 Diabetes mellitus 974 Diabetes and kidney diseases 3 B.8.1 228
230 975 Diabetes mellitus type 1 587 Diabetes mellitus 4 B.8.1.1 229
231 976 Diabetes mellitus type 2 587 Diabetes mellitus 4 B.8.1.2 230
232 589 Chronic kidney disease 974 Diabetes and kidney diseases 3 B.8.2 231
233 997 Chronic kidney disease due to diabetes mellitus type 1 589 Chronic kidney disease 4 B.8.2.1 232
234 998 Chronic kidney disease due to diabetes mellitus type 2 589 Chronic kidney disease 4 B.8.2.2 233
235 591 Chronic kidney disease due to hypertension 589 Chronic kidney disease 4 B.8.2.3 234
236 592 Chronic kidney disease due to glomerulonephritis 589 Chronic kidney disease 4 B.8.2.4 235
237 593 Chronic kidney disease due to other and unspecified causes 589 Chronic kidney disease 4 B.8.2.5 236
238 588 Acute glomerulonephritis 974 Diabetes and kidney diseases 3 B.8.3 237
239 653 Skin and subcutaneous diseases 409 Non-communicable diseases 2 B.9 238
240 654 Dermatitis 653 Skin and subcutaneous diseases 3 B.9.1 239 X
241 977 Atopic dermatitis 654 Dermatitis 4 B.9.1.1 240 X
242 978 Contact dermatitis 654 Dermatitis 4 B.9.1.2 241 X
243 979 Seborrhoeic dermatitis 654 Dermatitis 4 B.9.1.3 242 X
244 655 Psoriasis 653 Skin and subcutaneous diseases 3 B.9.2 243 X
245 980 Bacterial skin diseases 653 Skin and subcutaneous diseases 3 B.9.3 244
246 656 Cellulitis 980 Bacterial skin diseases 4 B.9.3.1 245
247 657 Pyoderma 980 Bacterial skin diseases 4 B.9.3.2 246
248 658 Scabies 653 Skin and subcutaneous diseases 3 B.9.4 247 X
249 659 Fungal skin diseases 653 Skin and subcutaneous diseases 3 B.9.5 248 X
250 660 Viral skin diseases 653 Skin and subcutaneous diseases 3 B.9.6 249 X
251 661 Acne vulgaris 653 Skin and subcutaneous diseases 3 B.9.7 250 X
252 662 Alopecia areata 653 Skin and subcutaneous diseases 3 B.9.8 251 X
253 663 Pruritus 653 Skin and subcutaneous diseases 3 B.9.9 252 X
254 664 Urticaria 653 Skin and subcutaneous diseases 3 B.9.10 253 X
255 665 Decubitus ulcer 653 Skin and subcutaneous diseases 3 B.9.11 254
256 668 Other skin and subcutaneous diseases 653 Skin and subcutaneous diseases 3 B.9.12 255
257 669 Sense organ diseases 409 Non-communicable diseases 2 B.10 256 X
258 981 Blindness and vision loss 669 Sense organ diseases 3 B.10.1 257 X
259 670 Glaucoma 981 Blindness and vision loss 4 B.10.1.1 258 X
260 671 Cataract 981 Blindness and vision loss 4 B.10.1.2 259 X
261 672 Age-related macular degeneration 981 Blindness and vision loss 4 B.10.1.3 260 X
262 999 Refraction disorders 981 Blindness and vision loss 4 B.10.1.4 261 X
263 1000 Near vision loss 981 Blindness and vision loss 4 B.10.1.5 262 X
264 675 Other vision loss 981 Blindness and vision loss 4 B.10.1.6 263 X
265 674 Age-related and other hearing loss 669 Sense organ diseases 3 B.10.2 264 X
266 679 Other sense organ diseases 669 Sense organ diseases 3 B.10.3 265 X
267 626 Musculoskeletal disorders 409 Non-communicable diseases 2 B.11 266
268 627 Rheumatoid arthritis 626 Musculoskeletal disorders 3 B.11.1 267
269 628 Osteoarthritis 626 Musculoskeletal disorders 3 B.11.2 268 X
270 1014 Osteoarthritis hip 628 Osteoarthritis 4 B.11.2.1 269 X
271 1015 Osteoarthritis knee 628 Osteoarthritis 4 B.11.2.2 270 X
272 1016 Osteoarthritis hand 628 Osteoarthritis 4 B.11.2.3 271 X
273 1017 Osteoarthritis other 628 Osteoarthritis 4 B.11.2.4 272 X
274 630 Low back pain 626 Musculoskeletal disorders 3 B.11.3 273 X
275 631 Neck pain 626 Musculoskeletal disorders 3 B.11.4 274 X
276 632 Gout 626 Musculoskeletal disorders 3 B.11.5 275 X
277 639 Other musculoskeletal disorders 626 Musculoskeletal disorders 3 B.11.6 276
278 640 Other non-communicable diseases 409 Non-communicable diseases 2 B.12 277
279 641 Congenital birth defects 640 Other non-communicable diseases 3 B.12.1 278
280 642 Neural tube defects 641 Congenital birth defects 4 B.12.1.1 279
281 643 Congenital heart anomalies 641 Congenital birth defects 4 B.12.1.2 280
282 644 Orofacial clefts 641 Congenital birth defects 4 B.12.1.3 281
283 645 Down syndrome 641 Congenital birth defects 4 B.12.1.4 282
284 646 Turner syndrome 641 Congenital birth defects 4 B.12.1.5 283 X
285 647 Klinefelter syndrome 641 Congenital birth defects 4 B.12.1.6 284 X
286 648 Other chromosomal abnormalities 641 Congenital birth defects 4 B.12.1.7 285
287 649 Congenital musculoskeletal and limb anomalies 641 Congenital birth defects 4 B.12.1.8 286
288 650 Urogenital congenital anomalies 641 Congenital birth defects 4 B.12.1.9 287
289 651 Digestive congenital anomalies 641 Congenital birth defects 4 B.12.1.10 288
290 652 Other congenital birth defects 641 Congenital birth defects 4 B.12.1.11 289
291 594 Urinary diseases and male infertility 640 Other non-communicable diseases 3 B.12.2 290
292 595 Urinary tract infections and interstitial nephritis 594 Urinary diseases and male infertility 4 B.12.2.1 291
293 596 Urolithiasis 594 Urinary diseases and male infertility 4 B.12.2.2 292
294 597 Benign prostatic hyperplasia 594 Urinary diseases and male infertility 4 B.12.2.3 293 X
295 598 Male infertility 594 Urinary diseases and male infertility 4 B.12.2.4 294 X
296 602 Other urinary diseases 594 Urinary diseases and male infertility 4 B.12.2.5 295
297 603 Gynecological diseases 640 Other non-communicable diseases 3 B.12.3 296
298 604 Uterine fibroids 603 Gynecological diseases 4 B.12.3.1 297
299 605 Polycystic ovarian syndrome 603 Gynecological diseases 4 B.12.3.2 298 X
300 606 Female infertility 603 Gynecological diseases 4 B.12.3.3 299 X
301 607 Endometriosis 603 Gynecological diseases 4 B.12.3.4 300
302 608 Genital prolapse 603 Gynecological diseases 4 B.12.3.5 301
303 609 Premenstrual syndrome 603 Gynecological diseases 4 B.12.3.6 302 X
304 612 Other gynecological diseases 603 Gynecological diseases 4 B.12.3.7 303
305 613 Hemoglobinopathies and hemolytic anemias 640 Other non-communicable diseases 3 B.12.4 304
306 614 Thalassemias 613 Hemoglobinopathies and hemolytic anemias 4 B.12.4.1 305
307 837 Thalassemias trait 613 Hemoglobinopathies and hemolytic anemias 4 B.12.4.2 306 X
308 615 Sickle cell disorders 613 Hemoglobinopathies and hemolytic anemias 4 B.12.4.3 307
309 838 Sickle cell trait 613 Hemoglobinopathies and hemolytic anemias 4 B.12.4.4 308 X
310 616 G6PD deficiency 613 Hemoglobinopathies and hemolytic anemias 4 B.12.4.5 309
311 839 G6PD trait 613 Hemoglobinopathies and hemolytic anemias 4 B.12.4.6 310 X
312 618 Other hemoglobinopathies and hemolytic anemias 613 Hemoglobinopathies and hemolytic anemias 4 B.12.4.7 311
313 619 Endocrine, metabolic, blood, and immune disorders 640 Other non-communicable diseases 3 B.12.5 312
314 680 Oral disorders 640 Other non-communicable diseases 3 B.12.6 313 X
315 681 Caries of deciduous teeth 680 Oral disorders 4 B.12.6.1 314 X
316 682 Caries of permanent teeth 680 Oral disorders 4 B.12.6.2 315 X
317 683 Periodontal diseases 680 Oral disorders 4 B.12.6.3 316 X
318 684 Edentulism 680 Oral disorders 4 B.12.6.4 317 X
319 685 Other oral disorders 680 Oral disorders 4 B.12.6.5 318 X
320 686 Sudden infant death syndrome 640 Other non-communicable diseases 3 B.12.7 319 X
321 687 Injuries 294 All causes 1 C 320
322 688 Transport injuries 687 Injuries 2 C.1 321
323 689 Road injuries 688 Transport injuries 3 C.1.1 322
324 690 Pedestrian road injuries 689 Road injuries 4 C.1.1.1 323
325 691 Cyclist road injuries 689 Road injuries 4 C.1.1.2 324
326 692 Motorcyclist road injuries 689 Road injuries 4 C.1.1.3 325
327 693 Motor vehicle road injuries 689 Road injuries 4 C.1.1.4 326
328 694 Other road injuries 689 Road injuries 4 C.1.1.5 327
329 695 Other transport injuries 688 Transport injuries 3 C.1.2 328
330 696 Unintentional injuries 687 Injuries 2 C.2 329
331 697 Falls 696 Unintentional injuries 3 C.2.1 330
332 698 Drowning 696 Unintentional injuries 3 C.2.2 331
333 699 Fire, heat, and hot substances 696 Unintentional injuries 3 C.2.3 332
334 700 Poisonings 696 Unintentional injuries 3 C.2.4 333
335 701 Poisoning by carbon monoxide 700 Poisonings 4 C.2.4.1 334
336 703 Poisoning by other means 700 Poisonings 4 C.2.4.2 335
337 704 Exposure to mechanical forces 696 Unintentional injuries 3 C.2.5 336
338 705 Unintentional firearm injuries 704 Exposure to mechanical forces 4 C.2.5.1 337
339 707 Other exposure to mechanical forces 704 Exposure to mechanical forces 4 C.2.5.2 338
340 708 Adverse effects of medical treatment 696 Unintentional injuries 3 C.2.6 339
341 709 Animal contact 696 Unintentional injuries 3 C.2.7 340
342 710 Venomous animal contact 709 Animal contact 4 C.2.7.1 341
343 711 Non-venomous animal contact 709 Animal contact 4 C.2.7.2 342
344 712 Foreign body 696 Unintentional injuries 3 C.2.8 343
345 713 Pulmonary aspiration and foreign body in airway 712 Foreign body 4 C.2.8.1 344
346 714 Foreign body in eyes 712 Foreign body 4 C.2.8.2 345 X
347 715 Foreign body in other body part 712 Foreign body 4 C.2.8.3 346
348 842 Environmental heat and cold exposure 696 Unintentional injuries 3 C.2.9 347
349 729 Exposure to forces of nature 696 Unintentional injuries 3 C.2.10 348
350 716 Other unintentional injuries 696 Unintentional injuries 3 C.2.11 349
351 717 Self-harm and interpersonal violence 687 Injuries 2 C.3 350
352 718 Self-harm 717 Self-harm and interpersonal violence 3 C.3.1 351
353 721 Self-harm by firearm 718 Self-harm 4 C.3.1.1 352
354 723 Self-harm by other specified means 718 Self-harm 4 C.3.1.2 353
355 724 Interpersonal violence 717 Self-harm and interpersonal violence 3 C.3.2 354
356 725 Physical violence by firearm 724 Interpersonal violence 4 C.3.2.1 355
357 726 Physical violence by sharp object 724 Interpersonal violence 4 C.3.2.2 356
358 941 Sexual violence 724 Interpersonal violence 4 C.3.2.3 357 X
359 727 Physical violence by other means 724 Interpersonal violence 4 C.3.2.4 358
360 945 Conflict and terrorism 717 Self-harm and interpersonal violence 3 C.3.3 359
361 854 Executions and police conflict 717 Self-harm and interpersonal violence 3 C.3.4 360
362 1029 Total cancers 294 All causes 1 D 361
363 1026 Total burden related to hepatitis B 294 All causes 1 E 362
364 1027 Total burden related to hepatitis C 294 All causes 1 F 363
365 1028 Total burden related to Non-alcoholic fatty liver disease (NAFLD) 294 All causes 1 G 364

@ -0,0 +1,248 @@
"Level"|"Chapter"|"chapter_code"|"start_code"|"end_code"|"group_name"
1|"I Certain infectious and parasitic diseases "|1|" A00 "|" B99 "|"I Certain infectious and parasitic diseases "
2|"I Certain infectious and parasitic diseases "|1|" A00 "|" A09 "|" Intestinal infectious diseases "
2|"I Certain infectious and parasitic diseases "|1|" A15 "|" A19 "|" Tuberculosis "
2|"I Certain infectious and parasitic diseases "|1|" A20 "|" A28 "|" Certain zoonotic bacterial diseases "
2|"I Certain infectious and parasitic diseases "|1|" A30 "|" A49 "|" Other bacterial diseases "
2|"I Certain infectious and parasitic diseases "|1|" A50 "|" A64 "|" Infections with a predominantly sexual mode of transmission "
2|"I Certain infectious and parasitic diseases "|1|" A65 "|" A69 "|" Other spirochaetal diseases "
2|"I Certain infectious and parasitic diseases "|1|" A70 "|" A74 "|" Other diseases caused by chlamydiae "
2|"I Certain infectious and parasitic diseases "|1|" A75 "|" A79 "|" Rickettsioses "
2|"I Certain infectious and parasitic diseases "|1|" A80 "|" A89 "|" Viral infections of the central nervous system "
2|"I Certain infectious and parasitic diseases "|1|" A92 "|" A99 "|" Arthropod-borne viral fevers and viral haemorrhagic fevers "
2|"I Certain infectious and parasitic diseases "|1|" B00 "|" B09 "|" Viral infections characterized by skin and mucous membrane lesions "
2|"I Certain infectious and parasitic diseases "|1|" B15 "|" B19 "|" Viral hepatitis "
2|"I Certain infectious and parasitic diseases "|1|" B20 "|" B24 "|" Human immunodeficiency virus [HIV] disease "
2|"I Certain infectious and parasitic diseases "|1|" B25 "|" B34 "|" Other viral diseases "
2|"I Certain infectious and parasitic diseases "|1|" B35 "|" B49 "|" Mycoses "
2|"I Certain infectious and parasitic diseases "|1|" B50 "|" B64 "|" Protozoal diseases "
2|"I Certain infectious and parasitic diseases "|1|" B65 "|" B83 "|" Helminthiases "
2|"I Certain infectious and parasitic diseases "|1|" B85 "|" B89 "|" Pediculosis, acariasis and other infestations "
2|"I Certain infectious and parasitic diseases "|1|" B90 "|" B94 "|" Sequelae of infectious and parasitic diseases "
2|"I Certain infectious and parasitic diseases "|1|" B95 "|" B98 "|" Bacterial, viral and other infectious agents "
2|"I Certain infectious and parasitic diseases "|1|" B99 "|" B99 "|" Other infectious diseases "
1|"II Neoplasms "|2|" C00 "|" D48 "|"II Neoplasms "
2|"II Neoplasms "|2|" C00 "|" C14 "|" Malignant neoplasms of lip, oral cavity and pharynx "
2|"II Neoplasms "|2|" C15 "|" C26 "|" Malignant neoplasms of digestive organs "
2|"II Neoplasms "|2|" C30 "|" C39 "|" Malignant neoplasms of respiratory and intrathoracic organs "
2|"II Neoplasms "|2|" C40 "|" C41 "|" Malignant neoplasms of bone and articular cartilage "
2|"II Neoplasms "|2|" C43 "|" C44 "|" Melanoma and other malignant neoplasms of skin "
2|"II Neoplasms "|2|" C45 "|" C49 "|" Malignant neoplasms of mesothelial and soft tissue "
2|"II Neoplasms "|2|" C50 "|" C50 "|" Malignant neoplasm of breast "
2|"II Neoplasms "|2|" C51 "|" C58 "|" Malignant neoplasms of female genital organs "
2|"II Neoplasms "|2|" C60 "|" C63 "|" Malignant neoplasms of male genital organs "
2|"II Neoplasms "|2|" C64 "|" C68 "|" Malignant neoplasms of urinary tract "
2|"II Neoplasms "|2|" C69 "|" C72 "|" Malignant neoplasms of eye, brain and other parts of central nervous system "
2|"II Neoplasms "|2|" C73 "|" C75 "|" Malignant neoplasms of thyroid and other endocrine glands "
2|"II Neoplasms "|2|" C76 "|" C80 "|" Malignant neoplasms of ill-defined, secondary and unspecified sites "
2|"II Neoplasms "|2|" C81 "|" C96 "|" Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue "
2|"II Neoplasms "|2|" C97 "|" C97 "|" Malignant neoplasms of independent (primary) multiple sites "
2|"II Neoplasms "|2|" D00 "|" D09 "|" In situ neoplasms "
2|"II Neoplasms "|2|" D10 "|" D36 "|" Benign neoplasms "
2|"II Neoplasms "|2|" D37 "|" D48 "|" Neoplasms of uncertain or unknown behaviour "
1|"III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism "|3|" D50 "|" D89 "|"III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism "
2|"III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism "|3|" D50 "|" D53 "|" Nutritional anaemias "
2|"III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism "|3|" D55 "|" D59 "|" Haemolytic anaemias "
2|"III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism "|3|" D60 "|" D64 "|" Aplastic and other anaemias "
2|"III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism "|3|" D65 "|" D69 "|" Coagulation defects, purpura and other haemorrhagic conditions "
2|"III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism "|3|" D70 "|" D77 "|" Other diseases of blood and blood-forming organs "
2|"III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism "|3|" D80 "|" D89 "|" Certain disorders involving the immune mechanism "
1|"IV Endocrine, nutritional and metabolic diseases "|4|" E00 "|" E90 "|"IV Endocrine, nutritional and metabolic diseases "
2|"IV Endocrine, nutritional and metabolic diseases "|4|" E00 "|" E07 "|" Disorders of thyroid gland "
2|"IV Endocrine, nutritional and metabolic diseases "|4|" E10 "|" E14 "|" Diabetes mellitus "
2|"IV Endocrine, nutritional and metabolic diseases "|4|" E15 "|" E16 "|" Other disorders of glucose regulation and pancreatic internal secretion "
2|"IV Endocrine, nutritional and metabolic diseases "|4|" E20 "|" E35 "|" Disorders of other endocrine glands "
2|"IV Endocrine, nutritional and metabolic diseases "|4|" E40 "|" E46 "|" Malnutrition "
2|"IV Endocrine, nutritional and metabolic diseases "|4|" E50 "|" E64 "|" Other nutritional deficiencies "
2|"IV Endocrine, nutritional and metabolic diseases "|4|" E65 "|" E68 "|" Obesity and other hyperalimentation "
2|"IV Endocrine, nutritional and metabolic diseases "|4|" E70 "|" E90 "|" Metabolic disorders "
1|"V Mental and behavioural disorders "|5|" F00 "|" F99 "|"V Mental and behavioural disorders "
2|"V Mental and behavioural disorders "|5|" F00 "|" F09 "|" Organic, including symptomatic, mental disorders "
2|"V Mental and behavioural disorders "|5|" F10 "|" F19 "|" Mental and behavioural disorders due to psychoactive substance use "
2|"V Mental and behavioural disorders "|5|" F20 "|" F29 "|" Schizophrenia, schizotypal and delusional disorders "
2|"V Mental and behavioural disorders "|5|" F30 "|" F39 "|" Mood [affective] disorders "
2|"V Mental and behavioural disorders "|5|" F40 "|" F48 "|" Neurotic, stress-related and somatoform disorders "
2|"V Mental and behavioural disorders "|5|" F50 "|" F59 "|" Behavioural syndromes associated with physiological disturbances and physical factors "
2|"V Mental and behavioural disorders "|5|" F60 "|" F69 "|" Disorders of adult personality and behaviour "
2|"V Mental and behavioural disorders "|5|" F70 "|" F79 "|" Mental retardation "
2|"V Mental and behavioural disorders "|5|" F80 "|" F89 "|" Disorders of psychological development "
2|"V Mental and behavioural disorders "|5|" F90 "|" F98 "|" Behavioural and emotional disorders with onset usually occurring in childhood and adolescence "
2|"V Mental and behavioural disorders "|5|" F99 "|" F99 "|" Unspecified mental disorder "
1|"VI Diseases of the nervous system "|6|" G00 "|" G99 "|"VI Diseases of the nervous system "
2|"VI Diseases of the nervous system "|6|" G00 "|" G09 "|" Inflammatory diseases of the central nervous system "
2|"VI Diseases of the nervous system "|6|" G10 "|" G14 "|" Systemic atrophies primarily affecting the central nervous system "
2|"VI Diseases of the nervous system "|6|" G20 "|" G26 "|" Extrapyramidal and movement disorders "
2|"VI Diseases of the nervous system "|6|" G30 "|" G32 "|" Other degenerative diseases of the nervous system "
2|"VI Diseases of the nervous system "|6|" G35 "|" G37 "|" Demyelinating diseases of the central nervous system "
2|"VI Diseases of the nervous system "|6|" G40 "|" G47 "|" Episodic and paroxysmal disorders "
2|"VI Diseases of the nervous system "|6|" G50 "|" G59 "|" Nerve, nerve root and plexus disorders "
2|"VI Diseases of the nervous system "|6|" G60 "|" G64 "|" Polyneuropathies and other disorders of the peripheral nervous system "
2|"VI Diseases of the nervous system "|6|" G70 "|" G73 "|" Diseases of myoneural junction and muscle "
2|"VI Diseases of the nervous system "|6|" G80 "|" G83 "|" Cerebral palsy and other paralytic syndromes "
2|"VI Diseases of the nervous system "|6|" G90 "|" G99 "|" Other disorders of the nervous system "
1|"VII Diseases of the eye and adnexa "|7|" H00 "|" H59 "|"VII Diseases of the eye and adnexa "
2|"VII Diseases of the eye and adnexa "|7|" H00 "|" H06 "|" Disorders of eyelid, lacrimal system and orbit "
2|"VII Diseases of the eye and adnexa "|7|" H10 "|" H13 "|" Disorders of conjunctiva "
2|"VII Diseases of the eye and adnexa "|7|" H15 "|" H22 "|" Disorders of sclera, cornea, iris and ciliary body "
2|"VII Diseases of the eye and adnexa "|7|" H25 "|" H28 "|" Disorders of lens "
2|"VII Diseases of the eye and adnexa "|7|" H30 "|" H36 "|" Disorders of choroid and retina "
2|"VII Diseases of the eye and adnexa "|7|" H40 "|" H42 "|" Glaucoma "
2|"VII Diseases of the eye and adnexa "|7|" H43 "|" H45 "|" Disorders of vitreous body and globe "
2|"VII Diseases of the eye and adnexa "|7|" H46 "|" H48 "|" Disorders of optic nerve and visual pathways "
2|"VII Diseases of the eye and adnexa "|7|" H49 "|" H52 "|" Disorders of ocular muscles, binocular movement, accommodation and refraction "
2|"VII Diseases of the eye and adnexa "|7|" H53 "|" H54 "|" Visual disturbances and blindness "
2|"VII Diseases of the eye and adnexa "|7|" H55 "|" H59 "|" Other disorders of eye and adnexa "
1|"VIII Diseases of the ear and mastoid process "|8|" H60 "|" H95 "|"VIII Diseases of the ear and mastoid process "
2|"VIII Diseases of the ear and mastoid process "|8|" H60 "|" H62 "|" Diseases of external ear "
2|"VIII Diseases of the ear and mastoid process "|8|" H65 "|" H75 "|" Diseases of middle ear and mastoid "
2|"VIII Diseases of the ear and mastoid process "|8|" H80 "|" H83 "|" Diseases of inner ear "
2|"VIII Diseases of the ear and mastoid process "|8|" H90 "|" H95 "|" Other disorders of ear "
1|"IX Diseases of the circulatory system "|9|" I00 "|" I99 "|"IX Diseases of the circulatory system "
2|"IX Diseases of the circulatory system "|9|" I00 "|" I02 "|" Acute rheumatic fever "
2|"IX Diseases of the circulatory system "|9|" I05 "|" I09 "|" Chronic rheumatic heart diseases "
2|"IX Diseases of the circulatory system "|9|" I10 "|" I15 "|" Hypertensive diseases "
2|"IX Diseases of the circulatory system "|9|" I20 "|" I25 "|" Ischaemic heart diseases "
2|"IX Diseases of the circulatory system "|9|" I26 "|" I28 "|" Pulmonary heart disease and diseases of pulmonary circulation "
2|"IX Diseases of the circulatory system "|9|" I30 "|" I52 "|" Other forms of heart disease "
2|"IX Diseases of the circulatory system "|9|" I60 "|" I69 "|" Cerebrovascular diseases "
2|"IX Diseases of the circulatory system "|9|" I70 "|" I79 "|" Diseases of arteries, arterioles and capillaries "
2|"IX Diseases of the circulatory system "|9|" I80 "|" I89 "|" Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified "
2|"IX Diseases of the circulatory system "|9|" I95 "|" I99 "|" Other and unspecified disorders of the circulatory system "
1|"X Diseases of the respiratory system "|10|" J00 "|" J99 "|"X Diseases of the respiratory system "
2|"X Diseases of the respiratory system "|10|" J00 "|" J06 "|" Acute upper respiratory infections "
2|"X Diseases of the respiratory system "|10|" J09 "|" J18 "|" Influenza and pneumonia "
2|"X Diseases of the respiratory system "|10|" J20 "|" J22 "|" Other acute lower respiratory infections "
2|"X Diseases of the respiratory system "|10|" J30 "|" J39 "|" Other diseases of upper respiratory tract "
2|"X Diseases of the respiratory system "|10|" J40 "|" J47 "|" Chronic lower respiratory diseases "
2|"X Diseases of the respiratory system "|10|" J60 "|" J70 "|" Lung diseases due to external agents "
2|"X Diseases of the respiratory system "|10|" J80 "|" J84 "|" Other respiratory diseases principally affecting the interstitium "
2|"X Diseases of the respiratory system "|10|" J85 "|" J86 "|" Suppurative and necrotic conditions of lower respiratory tract "
2|"X Diseases of the respiratory system "|10|" J90 "|" J94 "|" Other diseases of pleura "
2|"X Diseases of the respiratory system "|10|" J95 "|" J99 "|" Other diseases of the respiratory system "
1|"XI Diseases of the digestive system "|11|" K00 "|" K93 "|"XI Diseases of the digestive system "
2|"XI Diseases of the digestive system "|11|" K00 "|" K14 "|" Diseases of oral cavity, salivary glands and jaws "
2|"XI Diseases of the digestive system "|11|" K20 "|" K31 "|" Diseases of oesophagus, stomach and duodenum "
2|"XI Diseases of the digestive system "|11|" K35 "|" K38 "|" Diseases of appendix "
2|"XI Diseases of the digestive system "|11|" K40 "|" K46 "|" Hernia "
2|"XI Diseases of the digestive system "|11|" K50 "|" K52 "|" Noninfective enteritis and colitis "
2|"XI Diseases of the digestive system "|11|" K55 "|" K64 "|" Other diseases of intestines "
2|"XI Diseases of the digestive system "|11|" K65 "|" K67 "|" Diseases of peritoneum "
2|"XI Diseases of the digestive system "|11|" K70 "|" K77 "|" Diseases of liver "
2|"XI Diseases of the digestive system "|11|" K80 "|" K87 "|" Disorders of gallbladder, biliary tract and pancreas "
2|"XI Diseases of the digestive system "|11|" K90 "|" K93 "|" Other diseases of the digestive system "
1|"XII Diseases of the skin and subcutaneous tissue "|12|" L00 "|" L99 "|"XII Diseases of the skin and subcutaneous tissue "
2|"XII Diseases of the skin and subcutaneous tissue "|12|" L00 "|" L08 "|" Infections of the skin and subcutaneous tissue "
2|"XII Diseases of the skin and subcutaneous tissue "|12|" L10 "|" L14 "|" Bullous disorders "
2|"XII Diseases of the skin and subcutaneous tissue "|12|" L20 "|" L30 "|" Dermatitis and eczema "
2|"XII Diseases of the skin and subcutaneous tissue "|12|" L40 "|" L45 "|" Papulosquamous disorders "
2|"XII Diseases of the skin and subcutaneous tissue "|12|" L50 "|" L54 "|" Urticaria and erythema "
2|"XII Diseases of the skin and subcutaneous tissue "|12|" L55 "|" L59 "|" Radiation-related disorders of the skin and subcutaneous tissue "
2|"XII Diseases of the skin and subcutaneous tissue "|12|" L60 "|" L75 "|" Disorders of skin appendages "
2|"XII Diseases of the skin and subcutaneous tissue "|12|" L80 "|" L99 "|" Other disorders of the skin and subcutaneous tissue "
1|"XIII Diseases of the musculoskeletal system and connective tissue "|13|" M00 "|" M99 "|"XIII Diseases of the musculoskeletal system and connective tissue "
2|"XIII Diseases of the musculoskeletal system and connective tissue "|13|" M00 "|" M25 "|" Arthropathies "
2|"XIII Diseases of the musculoskeletal system and connective tissue "|13|" M30 "|" M36 "|" Systemic connective tissue disorders "
2|"XIII Diseases of the musculoskeletal system and connective tissue "|13|" M40 "|" M54 "|" Dorsopathies "
2|"XIII Diseases of the musculoskeletal system and connective tissue "|13|" M60 "|" M79 "|" Soft tissue disorders "
2|"XIII Diseases of the musculoskeletal system and connective tissue "|13|" M80 "|" M94 "|" Osteopathies and chondropathies "
2|"XIII Diseases of the musculoskeletal system and connective tissue "|13|" M95 "|" M99 "|" Other disorders of the musculoskeletal system and connective tissue "
1|"XIV Diseases of the genitourinary system "|14|" N00 "|" N99 "|"XIV Diseases of the genitourinary system "
2|"XIV Diseases of the genitourinary system "|14|" N00 "|" N08 "|" Glomerular diseases "
2|"XIV Diseases of the genitourinary system "|14|" N10 "|" N16 "|" Renal tubulo-interstitial diseases "
2|"XIV Diseases of the genitourinary system "|14|" N17 "|" N19 "|" Renal failure "
2|"XIV Diseases of the genitourinary system "|14|" N20 "|" N23 "|" Urolithiasis "
2|"XIV Diseases of the genitourinary system "|14|" N25 "|" N29 "|" Other disorders of kidney and ureter "
2|"XIV Diseases of the genitourinary system "|14|" N30 "|" N39 "|" Other diseases of urinary system "
2|"XIV Diseases of the genitourinary system "|14|" N40 "|" N51 "|" Diseases of male genital organs "
2|"XIV Diseases of the genitourinary system "|14|" N60 "|" N64 "|" Disorders of breast "
2|"XIV Diseases of the genitourinary system "|14|" N70 "|" N77 "|" Inflammatory diseases of female pelvic organs "
2|"XIV Diseases of the genitourinary system "|14|" N80 "|" N98 "|" Noninflammatory disorders of female genital tract "
2|"XIV Diseases of the genitourinary system "|14|" N99 "|" N99 "|" Other disorders of the genitourinary system "
1|"XV Pregnancy, childbirth and the puerperium "|15|" O00 "|" O99 "|"XV Pregnancy, childbirth and the puerperium "
2|"XV Pregnancy, childbirth and the puerperium "|15|" O00 "|" O08 "|" Pregnancy with abortive outcome "
2|"XV Pregnancy, childbirth and the puerperium "|15|" O10 "|" O16 "|" Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium "
2|"XV Pregnancy, childbirth and the puerperium "|15|" O20 "|" O29 "|" Other maternal disorders predominantly related to pregnancy "
2|"XV Pregnancy, childbirth and the puerperium "|15|" O30 "|" O48 "|" Maternal care related to the fetus and amniotic cavity and possible delivery problems "
2|"XV Pregnancy, childbirth and the puerperium "|15|" O60 "|" O75 "|" Complications of labour and delivery "
2|"XV Pregnancy, childbirth and the puerperium "|15|" O80 "|" O84 "|" Delivery "
2|"XV Pregnancy, childbirth and the puerperium "|15|" O85 "|" O92 "|" Complications predominantly related to the puerperium "
2|"XV Pregnancy, childbirth and the puerperium "|15|" O94 "|" O99 "|" Other obstetric conditions, not elsewhere classified "
1|"XVI Certain conditions originating in the perinatal period "|16|" P00 "|" P96 "|"XVI Certain conditions originating in the perinatal period "
2|"XVI Certain conditions originating in the perinatal period "|16|" P00 "|" P04 "|" Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery "
2|"XVI Certain conditions originating in the perinatal period "|16|" P05 "|" P08 "|" Disorders related to length of gestation and fetal growth "
2|"XVI Certain conditions originating in the perinatal period "|16|" P10 "|" P15 "|" Birth trauma "
2|"XVI Certain conditions originating in the perinatal period "|16|" P20 "|" P29 "|" Respiratory and cardiovascular disorders specific to the perinatal period "
2|"XVI Certain conditions originating in the perinatal period "|16|" P35 "|" P39 "|" Infections specific to the perinatal period "
2|"XVI Certain conditions originating in the perinatal period "|16|" P50 "|" P61 "|" Haemorrhagic and haematological disorders of fetus and newborn "
2|"XVI Certain conditions originating in the perinatal period "|16|" P70 "|" P74 "|" Transitory endocrine and metabolic disorders specific to fetus and newborn "
2|"XVI Certain conditions originating in the perinatal period "|16|" P75 "|" P78 "|" Digestive system disorders of fetus and newborn "
2|"XVI Certain conditions originating in the perinatal period "|16|" P80 "|" P83 "|" Conditions involving the integument and temperature regulation of fetus and newborn "
2|"XVI Certain conditions originating in the perinatal period "|16|" P90 "|" P96 "|" Other disorders originating in the perinatal period "
1|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q00 "|" Q99 "|"XVII Congenital malformations, deformations and chromosomal abnormalities "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q00 "|" Q07 "|" Congenital malformations of the nervous system "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q10 "|" Q18 "|" Congenital malformations of eye, ear, face and neck "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q20 "|" Q28 "|" Congenital malformations of the circulatory system "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q30 "|" Q34 "|" Congenital malformations of the respiratory system "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q35 "|" Q37 "|" Cleft lip and cleft palate "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q38 "|" Q45 "|" Other congenital malformations of the digestive system "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q50 "|" Q56 "|" Congenital malformations of genital organs "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q60 "|" Q64 "|" Congenital malformations of the urinary system "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q65 "|" Q79 "|" Congenital malformations and deformations of the musculoskeletal system "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q80 "|" Q89 "|" Other congenital malformations "
2|"XVII Congenital malformations, deformations and chromosomal abnormalities "|17|" Q90 "|" Q99 "|" Chromosomal abnormalities, not elsewhere classified "
1|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R00 "|" R99 "|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R00 "|" R09 "|" Symptoms and signs involving the circulatory and respiratory systems "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R10 "|" R19 "|" Symptoms and signs involving the digestive system and abdomen "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R20 "|" R23 "|" Symptoms and signs involving the skin and subcutaneous tissue "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R25 "|" R29 "|" Symptoms and signs involving the nervous and musculoskeletal systems "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R30 "|" R39 "|" Symptoms and signs involving the urinary system "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R40 "|" R46 "|" Symptoms and signs involving cognition, perception, emotional state and behaviour "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R47 "|" R49 "|" Symptoms and signs involving speech and voice "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R50 "|" R69 "|" General symptoms and signs "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R70 "|" R79 "|" Abnormal findings on examination of blood, without diagnosis "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R80 "|" R82 "|" Abnormal findings on examination of urine, without diagnosis "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R83 "|" R89 "|" Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R90 "|" R94 "|" Abnormal findings on diagnostic imaging and in function studies, without diagnosis "
2|"XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified "|18|" R95 "|" R99 "|" Ill-defined and unknown causes of mortality "
1|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S00 "|" T98 "|"XIX Injury, poisoning and certain other consequences of external causes "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S00 "|" S09 "|" Injuries to the head "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S10 "|" S19 "|" Injuries to the neck "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S20 "|" S29 "|" Injuries to the thorax "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S30 "|" S39 "|" Injuries to the abdomen, lower back, lumbar spine and pelvis "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S40 "|" S49 "|" Injuries to the shoulder and upper arm "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S50 "|" S59 "|" Injuries to the elbow and forearm "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S60 "|" S69 "|" Injuries to the wrist and hand "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S70 "|" S79 "|" Injuries to the hip and thigh "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S80 "|" S89 "|" Injuries to the knee and lower leg "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" S90 "|" S99 "|" Injuries to the ankle and foot "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T00 "|" T07 "|" Injuries involving multiple body regions "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T08 "|" T14 "|" Injuries to unspecified part of trunk, limb or body region "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T15 "|" T19 "|" Effects of foreign body entering through natural orifice "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T20 "|" T32 "|" Burns and corrosions "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T33 "|" T35 "|" Frostbite "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T36 "|" T50 "|" Poisoning by drugs, medicaments and biological substances "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T51 "|" T65 "|" Toxic effects of substances chiefly nonmedicinal as to source "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T66 "|" T78 "|" Other and unspecified effects of external causes "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T79 "|" T79 "|" Certain early complications of trauma "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T80 "|" T88 "|" Complications of surgical and medical care, not elsewhere classified "
2|"XIX Injury, poisoning and certain other consequences of external causes "|19|" T90 "|" T98 "|" Sequelae of injuries, of poisoning and of other consequences of external causes "
1|"XX External causes of morbidity and mortality "|20|" V01 "|" Y98 "|"XX External causes of morbidity and mortality "
2|"XX External causes of morbidity and mortality "|20|" V01 "|" X59 "|" Accidents "
2|"XX External causes of morbidity and mortality "|20|" X60 "|" X84 "|" Intentional self-harm "
2|"XX External causes of morbidity and mortality "|20|" X85 "|" Y09 "|" Assault "
2|"XX External causes of morbidity and mortality "|20|" Y10 "|" Y34 "|" Event of undetermined intent "
2|"XX External causes of morbidity and mortality "|20|" Y35 "|" Y36 "|" Legal intervention and operations of war "
2|"XX External causes of morbidity and mortality "|20|" Y40 "|" Y84 "|" Complications of medical and surgical care "
2|"XX External causes of morbidity and mortality "|20|" Y85 "|" Y89 "|" Sequelae of external causes of morbidity and mortality "
2|"XX External causes of morbidity and mortality "|20|" Y90 "|" Y98 "|" Supplementary factors related to causes of morbidity and mortality classified elsewhere "
1|"XXI Factors influencing health status and contact with health services "|21|" Z00 "|" Z99 "|"XXI Factors influencing health status and contact with health services "
2|"XXI Factors influencing health status and contact with health services "|21|" Z00 "|" Z13 "|" Persons encountering health services for examination and investigation "
2|"XXI Factors influencing health status and contact with health services "|21|" Z20 "|" Z29 "|" Persons with potential health hazards related to communicable diseases "
2|"XXI Factors influencing health status and contact with health services "|21|" Z30 "|" Z39 "|" Persons encountering health services in circumstances related to reproduction "
2|"XXI Factors influencing health status and contact with health services "|21|" Z40 "|" Z54 "|" Persons encountering health services for specific procedures and health care "
2|"XXI Factors influencing health status and contact with health services "|21|" Z55 "|" Z65 "|" Persons with potential health hazards related to socioeconomic and psychosocial circumstances "
2|"XXI Factors influencing health status and contact with health services "|21|" Z70 "|" Z76 "|" Persons encountering health services in other circumstances "
2|"XXI Factors influencing health status and contact with health services "|21|" Z80 "|" Z99 "|" Persons with potential health hazards related to family and personal history and certain conditions influencing health status "
1|"XXII Codes for special purposes "|22|" U00 "|" U85 "|"XXII Codes for special purposes "
2|"XXII Codes for special purposes "|22|" U00 "|" U49 "|" Provisional assignment of new diseases of uncertain etiology or emergency use "
2|"XXII Codes for special purposes "|22|" U82 "|" U85 "|" Resistance to antimicrobial and antineoplastic drugs "

@ -0,0 +1,225 @@
A00 | A09 | Intestinal infectious diseases
A15 | A19 | Tuberculosis
A20 | A28 | Certain zoonotic bacterial diseases
A30 | A49 | Other bacterial diseases
A50 | A64 | Infections with a predominantly sexual mode of transmission
A65 | A69 | Other spirochaetal diseases
A70 | A74 | Other diseases caused by chlamydiae
A75 | A79 | Rickettsioses
A80 | A89 | Viral infections of the central nervous system
A92 | A99 | Arthropod-borne viral fevers and viral haemorrhagic fevers
B00 | B09 | Viral infections characterized by skin and mucous membrane lesions
B15 | B19 | Viral hepatitis
B20 | B24 | Human immunodeficiency virus [HIV] disease
B25 | B34 | Other viral diseases
B35 | B49 | Mycoses
B50 | B64 | Protozoal diseases
B65 | B83 | Helminthiases
B85 | B89 | Pediculosis, acariasis and other infestations
B90 | B94 | Sequelae of infectious and parasitic diseases
B95 | B98 | Bacterial, viral and other infectious agents
B99 | B99 | Other infectious diseases
C00 | C14 | Malignant neoplasms of lip, oral cavity and pharynx
C15 | C26 | Malignant neoplasms of digestive organs
C30 | C39 | Malignant neoplasms of respiratory and intrathoracic organs
C40 | C41 | Malignant neoplasms of bone and articular cartilage
C43 | C44 | Melanoma and other malignant neoplasms of skin
C45 | C49 | Malignant neoplasms of mesothelial and soft tissue
C50 | C50 | Malignant neoplasm of breast
C51 | C58 | Malignant neoplasms of female genital organs
C60 | C63 | Malignant neoplasms of male genital organs
C64 | C68 | Malignant neoplasms of urinary tract
C69 | C72 | Malignant neoplasms of eye, brain and other parts of central nervous system
C73 | C75 | Malignant neoplasms of thyroid and other endocrine glands
C76 | C80 | Malignant neoplasms of ill-defined, secondary and unspecified sites
C81 | C96 | Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
C97 | C97 | Malignant neoplasms of independent (primary) multiple sites
D00 | D09 | In situ neoplasms
D10 | D36 | Benign neoplasms
D37 | D48 | Neoplasms of uncertain or unknown behaviour
D50 | D53 | Nutritional anaemias
D55 | D59 | Haemolytic anaemias
D60 | D64 | Aplastic and other anaemias
D65 | D69 | Coagulation defects, purpura and other haemorrhagic conditions
D70 | D77 | Other diseases of blood and blood-forming organs
D80 | D89 | Certain disorders involving the immune mechanism
E00 | E07 | Disorders of thyroid gland
E10 | E14 | Diabetes mellitus
E15 | E16 | Other disorders of glucose regulation and pancreatic internal secretion
E20 | E35 | Disorders of other endocrine glands
E40 | E46 | Malnutrition
E50 | E64 | Other nutritional deficiencies
E65 | E68 | Obesity and other hyperalimentation
E70 | E90 | Metabolic disorders
F00 | F09 | Organic, including symptomatic, mental disorders
F10 | F19 | Mental and behavioural disorders due to psychoactive substance use
F20 | F29 | Schizophrenia, schizotypal and delusional disorders
F30 | F39 | Mood [affective] disorders
F40 | F48 | Neurotic, stress-related and somatoform disorders
F50 | F59 | Behavioural syndromes associated with physiological disturbances and physical factors
F60 | F69 | Disorders of adult personality and behaviour
F70 | F79 | Mental retardation
F80 | F89 | Disorders of psychological development
F90 | F98 | Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
F99 | F99 | Unspecified mental disorder
G00 | G09 | Inflammatory diseases of the central nervous system
G10 | G14 | Systemic atrophies primarily affecting the central nervous system
G20 | G26 | Extrapyramidal and movement disorders
G30 | G32 | Other degenerative diseases of the nervous system
G35 | G37 | Demyelinating diseases of the central nervous system
G40 | G47 | Episodic and paroxysmal disorders
G50 | G59 | Nerve, nerve root and plexus disorders
G60 | G64 | Polyneuropathies and other disorders of the peripheral nervous system
G70 | G73 | Diseases of myoneural junction and muscle
G80 | G83 | Cerebral palsy and other paralytic syndromes
G90 | G99 | Other disorders of the nervous system
H00 | H06 | Disorders of eyelid, lacrimal system and orbit
H10 | H13 | Disorders of conjunctiva
H15 | H22 | Disorders of sclera, cornea, iris and ciliary body
H25 | H28 | Disorders of lens
H30 | H36 | Disorders of choroid and retina
H40 | H42 | Glaucoma
H43 | H45 | Disorders of vitreous body and globe
H46 | H48 | Disorders of optic nerve and visual pathways
H49 | H52 | Disorders of ocular muscles, binocular movement, accommodation and refraction
H53 | H54 | Visual disturbances and blindness
H55 | H59 | Other disorders of eye and adnexa
H60 | H62 | Diseases of external ear
H65 | H75 | Diseases of middle ear and mastoid
H80 | H83 | Diseases of inner ear
H90 | H95 | Other disorders of ear
I00 | I02 | Acute rheumatic fever
I05 | I09 | Chronic rheumatic heart diseases
I10 | I15 | Hypertensive diseases
I20 | I25 | Ischaemic heart diseases
I26 | I28 | Pulmonary heart disease and diseases of pulmonary circulation
I30 | I52 | Other forms of heart disease
I60 | I69 | Cerebrovascular diseases
I70 | I79 | Diseases of arteries, arterioles and capillaries
I80 | I89 | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
I95 | I99 | Other and unspecified disorders of the circulatory system
J00 | J06 | Acute upper respiratory infections
J09 | J18 | Influenza and pneumonia
J20 | J22 | Other acute lower respiratory infections
J30 | J39 | Other diseases of upper respiratory tract
J40 | J47 | Chronic lower respiratory diseases
J60 | J70 | Lung diseases due to external agents
J80 | J84 | Other respiratory diseases principally affecting the interstitium
J85 | J86 | Suppurative and necrotic conditions of lower respiratory tract
J90 | J94 | Other diseases of pleura
J95 | J99 | Other diseases of the respiratory system
K00 | K14 | Diseases of oral cavity, salivary glands and jaws
K20 | K31 | Diseases of oesophagus, stomach and duodenum
K35 | K38 | Diseases of appendix
K40 | K46 | Hernia
K50 | K52 | Noninfective enteritis and colitis
K55 | K64 | Other diseases of intestines
K65 | K67 | Diseases of peritoneum
K70 | K77 | Diseases of liver
K80 | K87 | Disorders of gallbladder, biliary tract and pancreas
K90 | K93 | Other diseases of the digestive system
L00 | L08 | Infections of the skin and subcutaneous tissue
L10 | L14 | Bullous disorders
L20 | L30 | Dermatitis and eczema
L40 | L45 | Papulosquamous disorders
L50 | L54 | Urticaria and erythema
L55 | L59 | Radiation-related disorders of the skin and subcutaneous tissue
L60 | L75 | Disorders of skin appendages
L80 | L99 | Other disorders of the skin and subcutaneous tissue
M00 | M25 | Arthropathies
M30 | M36 | Systemic connective tissue disorders
M40 | M54 | Dorsopathies
M60 | M79 | Soft tissue disorders
M80 | M94 | Osteopathies and chondropathies
M95 | M99 | Other disorders of the musculoskeletal system and connective tissue
N00 | N08 | Glomerular diseases
N10 | N16 | Renal tubulo-interstitial diseases
N17 | N19 | Renal failure
N20 | N23 | Urolithiasis
N25 | N29 | Other disorders of kidney and ureter
N30 | N39 | Other diseases of urinary system
N40 | N51 | Diseases of male genital organs
N60 | N64 | Disorders of breast
N70 | N77 | Inflammatory diseases of female pelvic organs
N80 | N98 | Noninflammatory disorders of female genital tract
N99 | N99 | Other disorders of the genitourinary system
O00 | O08 | Pregnancy with abortive outcome
O10 | O16 | Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
O20 | O29 | Other maternal disorders predominantly related to pregnancy
O30 | O48 | Maternal care related to the fetus and amniotic cavity and possible delivery problems
O60 | O75 | Complications of labour and delivery
O80 | O84 | Delivery
O85 | O92 | Complications predominantly related to the puerperium
O94 | O99 | Other obstetric conditions, not elsewhere classified
P00 | P04 | Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery
P05 | P08 | Disorders related to length of gestation and fetal growth
P10 | P15 | Birth trauma
P20 | P29 | Respiratory and cardiovascular disorders specific to the perinatal period
P35 | P39 | Infections specific to the perinatal period
P50 | P61 | Haemorrhagic and haematological disorders of fetus and newborn
P70 | P74 | Transitory endocrine and metabolic disorders specific to fetus and newborn
P75 | P78 | Digestive system disorders of fetus and newborn
P80 | P83 | Conditions involving the integument and temperature regulation of fetus and newborn
P90 | P96 | Other disorders originating in the perinatal period
Q00 | Q07 | Congenital malformations of the nervous system
Q10 | Q18 | Congenital malformations of eye, ear, face and neck
Q20 | Q28 | Congenital malformations of the circulatory system
Q30 | Q34 | Congenital malformations of the respiratory system
Q35 | Q37 | Cleft lip and cleft palate
Q38 | Q45 | Other congenital malformations of the digestive system
Q50 | Q56 | Congenital malformations of genital organs
Q60 | Q64 | Congenital malformations of the urinary system
Q65 | Q79 | Congenital malformations and deformations of the musculoskeletal system
Q80 | Q89 | Other congenital malformations
Q90 | Q99 | Chromosomal abnormalities, not elsewhere classified
R00 | R09 | Symptoms and signs involving the circulatory and respiratory systems
R10 | R19 | Symptoms and signs involving the digestive system and abdomen
R20 | R23 | Symptoms and signs involving the skin and subcutaneous tissue
R25 | R29 | Symptoms and signs involving the nervous and musculoskeletal systems
R30 | R39 | Symptoms and signs involving the urinary system
R40 | R46 | Symptoms and signs involving cognition, perception, emotional state and behaviour
R47 | R49 | Symptoms and signs involving speech and voice
R50 | R69 | General symptoms and signs
R70 | R79 | Abnormal findings on examination of blood, without diagnosis
R80 | R82 | Abnormal findings on examination of urine, without diagnosis
R83 | R89 | Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
R90 | R94 | Abnormal findings on diagnostic imaging and in function studies, without diagnosis
R95 | R99 | Ill-defined and unknown causes of mortality
S00 | S09 | Injuries to the head
S10 | S19 | Injuries to the neck
S20 | S29 | Injuries to the thorax
S30 | S39 | Injuries to the abdomen, lower back, lumbar spine and pelvis
S40 | S49 | Injuries to the shoulder and upper arm
S50 | S59 | Injuries to the elbow and forearm
S60 | S69 | Injuries to the wrist and hand
S70 | S79 | Injuries to the hip and thigh
S80 | S89 | Injuries to the knee and lower leg
S90 | S99 | Injuries to the ankle and foot
T00 | T07 | Injuries involving multiple body regions
T08 | T14 | Injuries to unspecified part of trunk, limb or body region
T15 | T19 | Effects of foreign body entering through natural orifice
T20 | T32 | Burns and corrosions
T33 | T35 | Frostbite
T36 | T50 | Poisoning by drugs, medicaments and biological substances
T51 | T65 | Toxic effects of substances chiefly nonmedicinal as to source
T66 | T78 | Other and unspecified effects of external causes
T79 | T79 | Certain early complications of trauma
T80 | T88 | Complications of surgical and medical care, not elsewhere classified
T90 | T98 | Sequelae of injuries, of poisoning and of other consequences of external causes
V01 | X59 | Accidents
X60 | X84 | Intentional self-harm
X85 | Y09 | Assault
Y10 | Y34 | Event of undetermined intent
Y35 | Y36 | Legal intervention and operations of war
Y40 | Y84 | Complications of medical and surgical care
Y85 | Y89 | Sequelae of external causes of morbidity and mortality
Y90 | Y98 | Supplementary factors related to causes of morbidity and mortality classified elsewhere
Z00 | Z13 | Persons encountering health services for examination and investigation
Z20 | Z29 | Persons with potential health hazards related to communicable diseases
Z30 | Z39 | Persons encountering health services in circumstances related to reproduction
Z40 | Z54 | Persons encountering health services for specific procedures and health care
Z55 | Z65 | Persons with potential health hazards related to socioeconomic and psychosocial circumstances
Z70 | Z76 | Persons encountering health services in other circumstances
Z80 | Z99 | Persons with potential health hazards related to family and personal history and certain conditions influencing health status
U00 | U49 | Provisional assignment of new diseases of uncertain etiology or emergency use
U82 | U85 | Resistance to antimicrobial and antineoplastic drugs

@ -40,7 +40,25 @@ with postgres_conn() as pconn, pconn.cursor(cursor_factory=extras.DictCursor) as
order by nct_id
;
"""
pcurse.execute(sql)
sql2 = """
with cte as (
/* Keywords added too much noise
select nct_id,downcase_name
from ctgov.keywords k
where nct_id in (select distinct nct_id from history.trial_snapshots ts)
union */
select nct_id, downcase_name
from ctgov.conditions c
union
select nct_id ,downcase_mesh_term as downcase_name
from ctgov.browse_conditions bc
where mesh_type = 'mesh-list'
)
select nct_id, downcase_name from cte
where nct_id in (select distinct nct_id from history.trial_snapshots ts)
order by nct_id
"""
pcurse.execute(sql2)
rows = pcurse.fetchall()
entries = []

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