added details to causal story, enabled latex todos, updated laptop layout

claude_rewrite
Will King 1 year ago
parent e2576b5fc1
commit 70c2eeb5f5

@ -33,7 +33,7 @@ layout {
} }
} }
tab name="sections" cwd="~/research/phd_deliverables/jmp/Latex/Paper" { tab name="sections" cwd="~/research/phd_deliverables/jmp/Latex/Paper/sections" {
pane size=1 borderless=true { pane size=1 borderless=true {
plugin location="tab-bar" plugin location="tab-bar"
} }

@ -110,7 +110,9 @@ it continues to completion.
\tikzfig{../assets/tikzit/CausalGraph2} \tikzfig{../assets/tikzit/CausalGraph2}
} }
} }
\todo{check if this is the correct graph}
\caption{Graphical Causal Model} \caption{Graphical Causal Model}
% \small{Crimson boxes are the variables of interest, % \small{Crimson boxes are the variables of interest,
% white boxes are unobserved, while the gray boxes will be controlled for.} % white boxes are unobserved, while the gray boxes will be controlled for.}
\label{Fig:CausalModel} \label{Fig:CausalModel}
@ -119,9 +121,10 @@ it continues to completion.
% Constructing the model more explicitly % Constructing the model more explicitly
% - quickly describe each node and line. % - quickly describe each node and line.
% TODO: double check which graphic to use. \todo{I think I need to blend the data section in before this, to give some overall information on data.}
\todo{I may need to add some information on snapshots so that this makes sense.}
A quick summary of the nodes of the DAG and their impact: A quick summary of the nodes of the DAG, the exact representation in the data, and their impact:
\begin{itemize} \begin{itemize}
\item Main Interests (Crimson Boxes) \item Main Interests (Crimson Boxes)
\begin{enumerate} \begin{enumerate}
@ -129,21 +132,34 @@ A quick summary of the nodes of the DAG and their impact:
If the final status of the trial was \textit{terminated} If the final status of the trial was \textit{terminated}
or \textit{completed}. or \textit{completed}.
\item \texttt{Enrollment Status}: \item \texttt{Enrollment Status}:
Measure of whether enrollment is progressing. This describes the current enrollment status of the snapshot, e.g.
\texttt{Recruiting},
\texttt{Enrolling by invitation only},
or
\texttt{Active, not recruting}.
\item \texttt{Market Measures}: \item \texttt{Market Measures}:
Various measures of the number of alternate drugs on the market. Various measures of the number of alternate drugs on the market.
These are either the number of other drugs with the same active ingredient as the trial
(both generic and originators),
and those considered alternatives in various formularies published by the United States Pharmacopeia.
\end{enumerate} \end{enumerate}
\item Observed Confounders (Gray Boxes) \item Observed Confounders (Gray Boxes)
\begin{enumerate} \begin{enumerate}
\item \texttt{Condition}: \item \texttt{Condition}:
The underlying condition. The underlying condition, classified by IDC-10 group.
This impacts every other aspect of the model. This impacts every other aspect of the model.
\item \texttt{Population (market size)}: \item \texttt{Population (market size)}:
Multiple measures of the impact the disease has (in DALYs). Multiple measures of the impact the disease.
These are measured by the DALY cost of the disease in countries that have a
High, High-Medium, Medium, Medium-Low, and Low development scores.
This data comes from the Institute for Health Metrics' Global Burden of Disease study.
\item \texttt{Elapsed Duration}: \item \texttt{Elapsed Duration}:
A normalized measure of the trial progression. A normalized measure of the time elapsed in the trial.
Comes from the original estimate of the trial's primary completion date and the registered start date.
I take the difference in days between these, and get the percentage of that time that has elapsed.
\item \texttt{Decision to Proceed with Phase III}: \item \texttt{Decision to Proceed with Phase III}:
If the compound development has progressed to Phase III. If the compound development has progressed to Phase III.
This is included in the analysis by only including Phase III trials.
\end{enumerate} \end{enumerate}
\item Unobserved Confounders (White Boxes) \item Unobserved Confounders (White Boxes)
\begin{enumerate} \begin{enumerate}
@ -151,9 +167,12 @@ A quick summary of the nodes of the DAG and their impact:
The underlying safety of the compound. The underlying safety of the compound.
Cannot be observed, only estimated through scientific study. Cannot be observed, only estimated through scientific study.
\item \texttt{Previously observed Efficacy and Safety}: \item \texttt{Previously observed Efficacy and Safety}:
The information gathered in previous studies. The information gathered in previous studies.
This is not available in my dataset because I don't have links to prior studies.
\item \texttt{Currently observed Efficiency and Safety}: \item \texttt{Currently observed Efficiency and Safety}:
The information gathered during this study. The information gathered during this study.
This is only partially available, and so is treated as unavailable.
After a study is over, the investigators are supposed to publish information about adverse events.
\end{enumerate} \end{enumerate}
\end{itemize} \end{itemize}

@ -2,6 +2,7 @@
\usepackage{booktabs} % Allows the use of \toprule, \midrule and \bottomrule in tables \usepackage{booktabs} % Allows the use of \toprule, \midrule and \bottomrule in tables
\usepackage{hyperref} %Includes Hyperlinks \usepackage{hyperref} %Includes Hyperlinks
\usepackage{cleveref} %Simplifies citations and references \usepackage{cleveref} %Simplifies citations and references
\usepackage{todonotes} % Allows using todo-notes
%Setup some language stuff %Setup some language stuff

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