diff --git a/Concept-paper-2022-02-09.md b/Concept-paper-2022-02-09.md index b6f5a22..2854dd7 100644 --- a/Concept-paper-2022-02-09.md +++ b/Concept-paper-2022-02-09.md @@ -12,6 +12,11 @@ I think I can get two, maybe three, papers out of this: - What is the impact of surragate endpoints on phase transition completion? on phase transition? # Models +The general benefit I can provide is to: + +- Create a straightforward replication/update pathway. +- Model based on information known at the beginning of the trial. + - This might allow me to escape [[EK]]'s markov modeling approach for phase transitions. ## Phase completion: Joint Probability Estimation (single paper?) @@ -33,7 +38,8 @@ trying to separate out probability of scientific vs market drops. This would use the IND or similar data to build the list of phase transitions. -### Design tradeoffs +### Design tradeoffs. + Some design tradeoffs include - Normalized or non-normalized transition paths? I'm particularly interested in inclucing mixed-phase paths, i.e. non-normalized paths.