From b859ed7d4c377f01ef5ed5b8a7fbab4c1d032e7b Mon Sep 17 00:00:00 2001 From: will king Date: Mon, 9 Sep 2024 16:14:53 -0700 Subject: [PATCH] updating lit review and data stuff --- Latex/Paper/sections/05_LitReview.tex | 27 +++++++++++++++++++++++++-- 1 file changed, 25 insertions(+), 2 deletions(-) diff --git a/Latex/Paper/sections/05_LitReview.tex b/Latex/Paper/sections/05_LitReview.tex index 788396c..81d27fd 100644 --- a/Latex/Paper/sections/05_LitReview.tex +++ b/Latex/Paper/sections/05_LitReview.tex @@ -77,11 +77,34 @@ higher if those strategic terminatations were elimintated. % - In general, there are going to be many confounding variables. % - % -% + +% van der grong et al 2017 Addressing the challenge of high-price prescription drugs +% Massive number of policies used to try to reduce costs. These will affect production decisions. +% Some of the unintended consequences of that (in terms of reduced development incentives) include +% - reducing development costs - side effect of lower quality evidence +% - Preference policy (e.g. policies about using generics first etc) - side effect of shorter life cycle for patented (novel) drugs. +% - these are focused on reducing expenditures, i.e. they reduce profit. Some of them feed back into the development process. +% - % Dranov, Garthwaite, and Hermosilla (2022) % - does the demand-pull theory of R&D explain novel compound development? -% - no, it is biased towards follow-on drug R&D. +% - no, when demand increased (creation of medicare part-D), investement in previously approved drugs grew the most. + +% Cerda 2007 - Endogenous innovations in the pharmaceutical industry +% from abstract %TODO: Read better +% Market size, population, and existence of drugs are endogenous +% from the abstract I get the impresssion that it is: +% - large population -> large market -> more profitable -> more drugs +% - more drugs -> better survivability -> larger market +% Applicable because: Need to separate population and market effects. +% Does this mess with my results? I don't think so because of the relatively short time in trials. Not enough time to effect population back, but it might have another effect. + + +% Dubois et al 2015 - Market Size and pharmaceutical innovation +% from abstract %TODO: Read better +% estimate the relationship between marekt size and the innovation in pharmaceuticals +% elasticity of innovation w.r.t. expected market size of 0.23, thus $2.5 billion in +% market size required to get a new chemical entity. % Acemoglu and Linn % - Market size in innovation