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		\node [style=emptyBox] (4) at (-6, -7.5) {Unobserved};
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		\node [style=Red Box] (8) at (-5.75, -6) {Relationships of interest};
		\node [style=emptyBox] (9) at (12.25, 6.25) {Fundamental Efficacy/Safety};
		\node [style=emptyBox] (10) at (-0.25, 8) {Previously Observed Efficacy/Safety};
		\node [style=emptyBox] (12) at (14, 0.25) {Currently Observed Efficacy/Safety};
		\node [style=Gray Box] (13) at (7, -6) {Observed};
		\node [style=Gray Box] (18) at (-6.5, 1.5) {Population};
		\node [style=Gray Box] (20) at (-0.25, 5) {Decision to procced with Phase III};
		\node [style=Gray Box] (21) at (0, -3.5) {Condition};
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